Flow diverters failing to occlude experimental bifurcation or curved sidewall aneurysms: an in vivo study in canines

Journal of Neurosurgery
Tim E DarsautJean Raymond

Abstract

Flow diverters (FDs) are increasingly used to treat complex intracranial aneurysms, but preclinical studies that could guide clinical applications are lacking. The authors designed a modular aneurysm model in canines to address this problem. Three variants of one modular aneurysm model were constructed in 21 animals. Sidewall (n=5), curved sidewall (n=5), and end-wall bifurcation (n=7) aneurysms were treated with prototype 36-wire FDs. Four more end-wall bifurcation aneurysms were treated with prototype 48-wire lower-porosity FDs. Angiographic results postimplantation and at 3 months were scored with an ordinal scale. Animals were euthanized at 3 (n=17) or 6 (n=3) months, and the FD covering the aneurysm ostium was photographed to analyze metallic porosity and amount of neointima formation. Straight sidewall aneurysms were better occluded than curved sidewall and end-wall bifurcation aneurysms at the 3-month angiography follow-up (p=0.010). Flow diverters failed to occlude curved sidewall aneurysms (n=0/5) and all but one (n=1/7) end-wall bifurcation aneurysm. Angiographic results were no better (n=0/4) using a 48-wire FD (p=0.788). Branches jailed by the FD (n=16) remained patent in all cases. Metallic porosity was decreased (...Continue Reading

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Citations

Jul 12, 2012·Journal of Neurointerventional Surgery·Tim E DarsautJean Raymond
Jun 27, 2014·Stroke Research and Treatment·Yazan J AlderaziChirag D Gandhi
Feb 19, 2014·Neuroradiology·Mario ZanatyPascal Jabbour
Aug 11, 2012·AJNR. American Journal of Neuroradiology·A MakoyevaJ Raymond
Jan 3, 2016·World Neurosurgery·Osman Melih TopcuogluAnil Arat
Jan 9, 2016·Journal of Neurosurgery·Tim E DarsautJean Raymond
Jul 22, 2014·Journal of Biomedical Materials Research. Part a·Jennifer N RodriguezDuncan J Maitland
Jan 17, 2015·AJNR. American Journal of Neuroradiology·T E DarsautJ Raymond
Jan 19, 2016·World Neurosurgery·Badih Daou, Pascal Jabbour
Nov 26, 2016·AJNR. American Journal of Neuroradiology·R FahedJ Raymond
Apr 26, 2017·World Neurosurgery·Pervinder BhogalMarta Aguilar Pérez
Jun 13, 2017·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Liang-Der Jou
Mar 8, 2018·The Neuroradiology Journal·Robert FahedJean Raymond
Dec 15, 2017·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Ronak J DholakiaChander Sadasivan
Jan 24, 2019·European Radiology Experimental·Rosa Martínez MorenoHans Henkes
Aug 1, 2014·Journal of Neurointerventional Surgery·B FarzinJ Raymond
Mar 1, 2017·Neuroradiology·Robert FahedJean Raymond
Mar 5, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Serge MarbacherJavier Fandino
Dec 21, 2013·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Alina MakoyevaJean Raymond
Oct 11, 2015·Journal of Neurointerventional Surgery·Jean-Christophe GentricTim Darsaut
May 17, 2017·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Takashi SuzukiMakoto Yamamoto
Feb 18, 2017·Frontiers in Neurology·Pervinder BhogalMarta Aguilar Pérez
Jun 27, 2020·Scientific Reports·Kamil Jerzy ChodzyǹskiKarim Zouaoui Boudjeltia

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