Flow effect on lesion formation in RF cardiac catheter ablation

IEEE Transactions on Bio-medical Engineering
Hong CaoJohn G Webster

Abstract

This study investigated the flow effect on the lesion formation during radio-frequency cardiac catheter ablation in temperature-controlled mode. The blood flow in heart chambers carries heat away from the endocardium by convection. This cooling effect requires more power from the ablation generator and causes a larger lesion. We set up a flow system to simulate the flow inside the heart chamber. We performed in vitro ablation on bovine myocardium with three different flow rates (0 L/min, 1 L/min and 3 L/min) and two target temperatures (60 degrees C and 80 degrees C). During ablation, we also recorded the temperatures inside the myocardium with a three-thermocouple temperature probe. The results show that lesion dimensions (maximum depth, maximum width and lesion volume) are larger in high flow rates (p<0.01). Also, the temperature recordings show that the tissue temperature rises faster and reaches a higher temperature under higher flow rate.

References

Feb 1, 1994·IEEE Transactions on Bio-medical Engineering·S Labonté
Feb 1, 1997·IEEE Transactions on Bio-medical Engineering·K HynynenM Aguirre
Feb 18, 1999·The New England Journal of Medicine·F Morady
Dec 29, 1999·IEEE Transactions on Bio-medical Engineering·M K Jain, P D Wolf
Nov 15, 2000·IEEE Transactions on Bio-medical Engineering·H CaoJ G Webster
Apr 12, 2001·IEEE Transactions on Bio-medical Engineering·S TungjitkusolmunJ G Webster

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Citations

May 1, 2015·Science Translational Medicine·Abraham R TzafririElazer R Edelman
Jan 5, 2007·Pacing and Clinical Electrophysiology : PACE·Thomas A PilcherDieter Haemmerich
Mar 1, 2008·Pacing and Clinical Electrophysiology : PACE·Thomas A PilcherDieter Haemmerich
Apr 20, 2011·Pacing and Clinical Electrophysiology : PACE·Choonghee LeeSeil Oh
Mar 6, 2002·IEEE Transactions on Bio-medical Engineering·Hong CaoJohn G Webster
Apr 1, 2003·IEEE Transactions on Bio-medical Engineering·Jie ZhangJohn G Webster
Oct 20, 2004·IEEE Transactions on Bio-medical Engineering·Yu-Chi LaiJohn G Webster
Aug 11, 2015·IEEE Transactions on Bio-medical Engineering·A González-Suárez, E Berjano
Aug 19, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·José Alba-MartínezEnrique Berjano
Dec 18, 2013·The Journal of Urology·Achim LuschJaime Landman
Sep 26, 2003·Physiological Measurement·Icaro dos SantosJonathan W Valvano
May 31, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Juan J PérezEnrique Berjano
Jun 30, 2016·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Pieter W J LozekootSandro Gelsomino
Jun 19, 2003·Physiological Measurement·Icaro dos SantosJonathan W Valvano

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