Flow field analysis in a compliant acinus replica model using particle image velocimetry (PIV)

Journal of Biomechanics
Emily J BergRisa J Robinson

Abstract

Inhaled particles reaching the alveolar walls have the potential to cross the blood-gas barrier and enter the blood stream. Experimental evidence of pulmonary dosimetry, however, cannot be explained by current whole lung dosimetry models. Numerical and experimental studies shed some light on the mechanisms of particle transport, but realistic geometries have not been investigated. In this study, a three dimensional expanding model including two generations of respiratory bronchioles and five terminal alveolar sacs was created from a replica human lung cast. Flow visualization techniques were employed to quantify the fluid flow while utilizing streamlines to evaluate recirculation. Pathlines were plotted to track the fluid motion and estimate penetration depth of inhaled air. This study provides evidence that the two generations immediately proximal to the terminal alveolar sacs do not have recirculating eddies, even for intense breathing. Results of Peclet number calculations indicate that substantial convective motion is present in vivo for the case of deep breathing, which significantly increases particle penetration into the alveoli. However, particle diffusion remains the dominant mechanism of particle transport over convec...Continue Reading

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Apr 8, 2010·Journal of Biomechanical Engineering·Jessica M OakesRisa J Robinson

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Citations

Nov 28, 2012·Journal of Biomechanics·Josué Sznitman
Feb 19, 2011·Journal of Applied Physiology·Baoshun Ma, Chantal Darquenne
Apr 17, 2014·Journal of Biomechanics·Ross L WalengaGobalakrishnan Sundaresan
Nov 11, 2014·Journal of Aerosol Science·Navvab Khajeh-Hosseini-Dalasm, P Worth Longest
Jun 7, 2011·Advanced Drug Delivery Reviews·P Worth Longest, Landon T Holbrook
Oct 5, 2013·Journal of Biomechanics·Rami FishlerJosué Sznitman
Dec 16, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jinxiang XiYue Zhou
Jul 13, 2011·Journal of Biomechanical Engineering·Emily J Berg, Risa J Robinson
Dec 8, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Peter R ByronWarren H Finlay
Sep 7, 2013·Journal of Biomechanical Engineering·Arun V Kolanjiyil, Clement Kleinstreuer
May 14, 2010·Inhalation Toxicology·Edward M Harding, Risa J Robinson
Feb 14, 2019·Computational and Mathematical Methods in Medicine·Arun V Kolanjiyil, Clement Kleinstreuer
Oct 26, 2018·Computational and Mathematical Methods in Medicine·Jinxiang XiKhaled Talaat
Oct 4, 2020·Respiratory Physiology & Neurobiology·Jinxiang XiHiroko Kitaoka

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