Flow-induced arterial remodeling in rat mesenteric vasculature

The American Journal of Physiology
D A TulisR L Prewitt

Abstract

This study was designed to characterize in vivo arterial remodeling of male Wistar rat small mesenteric arteries exposed to varying levels of elevated blood flow in the presence of normal arterial pressure. Through a series of arterial ligations, respective ileal artery and second-order branch blood flows acutely increased approximately 36 and approximately 170% over basal levels. Their respective diameters increased 12 and 38% and their wall area increased 58 and 120% in a time-dependent fashion between 1 and 7 days postlitigation compared with same-animal control vessels. Medical extracellular connective tissue increased concomitantly with medical wall hypertrophy. Immunostaining for proliferating cell nuclear antigen and nuclear profile analyses suggests that both smooth muscle and endothelial cell hyperplasia contribute to flow-induced vascular remodeling. The initial stimulus in this model is flow-mediated shear stress, with possible augmentation by hoop stress, which is increased approximately 7% by the resultant vasodilation. Stable wall thickness-to-lumen diameter ratios at 1, 3, and 7 days, however, suggest chronic hoop stress is tightly regulated and remains constant. The model described herein allows analyses of two ...Continue Reading

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Citations

Feb 8, 2003·American Journal of Physiology. Heart and Circulatory Physiology·A R PriesT W Secomb
Jul 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Richard C BrunkenHeinrich R Schelbert
Jul 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Tara L HaasJoseph L Unthank
Nov 18, 2008·Canadian Journal of Physiology and Pharmacology·Yu-Jing GaoRobert M K W Lee
Feb 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jo G R De MeyMarijke M W Sanders
Aug 22, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Markus ReschDierk H Endemann
Jan 11, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
Jan 31, 2009·Journal of Applied Physiology·Marisa Garcia, Ghassan S Kassab
Jul 5, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ed VanBavelJos A E Spaan
May 5, 2007·Journal of Applied Physiology·Cassandra E Morris, Thomas C Skalak
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Oct 27, 2020·Aging Medicine·Tianqi Ma, Yong-Ping Bai

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