Flow-induced deformation in a microchannel with a non-Newtonian fluid

Biomicrofluidics
Kiran Raj MSuman Chakraborty

Abstract

In this work, we have fabricated physiologically relevant polydimethylsiloxane microfluidic phantoms to investigate the fluid-structure interaction that arises from the interaction between a non-Newtonian fluid and the deformable wall. A shear thinning fluid (Xanthan gum solution) is used as the blood analog fluid. We have systematically analyzed the steady flow characteristics of the microfluidic phantom using pressure drop, deformation, and flow visualization using micro-PIV (Particle Image Velocimetry) to identify the intricate aspects of the pressure as well as the velocity field. A simple mathematical formulation is introduced to evaluate the flow induced deformation. These results will aid in the design and development of deformable microfluidic systems and provide a deeper understanding of the fluid-structure interaction in microchannels with special emphasis on biomimetic in-vitro models for lab-on-a-chip applications.

References

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Citations

Nov 27, 2018·Lab on a Chip·Kiran Raj MSuman Chakraborty
Dec 12, 2019·Proceedings. Mathematical, Physical, and Engineering Sciences·Xiaojia Wang, Ivan C Christov
Mar 15, 2019·Biomicrofluidics·Kiran Raj MSuman Chakraborty
Dec 5, 2019·Micromachines·Hedieh FallahiNam-Trung Nguyen
Oct 23, 2021·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Ivan C Christov
Dec 1, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·A-Reum KimBoxin Zhao

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