Flow-induced dissolution of femtoliter surface droplet arrays

Lab on a Chip
Lei BaoXuehua Zhang

Abstract

The dissolution of liquid nanodroplets is a crucial step in many applied processes, such as separation and dispersion in the food industry, crystal formation of pharmaceutical products, concentrating and analysis in medical diagnosis, and drug delivery in aerosols. In this work, using both experiments and numerical simulations, we quantitatively study the dissolution dynamics of femtoliter surface droplets in a highly ordered array under a uniform flow. Our results show that the dissolution of femtoliter droplets strongly depends on their spatial positions relative to the flow direction, drop-to-drop spacing in the array, and the imposed flow rate. In some particular cases, the droplet at the edge of the array can dissolve about 30% faster than the ones located near the centre. The dissolution rate of the droplet increases by 60% as the inter-droplet spacing is increased from 2.5 μm to 20 μm. Moreover, the droplets close to the front of the flow commence to shrink earlier than those droplets in the center of the array. The average dissolution rate is faster for the faster flow. As a result, the dissolution time (Ti) decreases with the Reynolds number (Re) of the flow as Ti ∝ Re-3/4. The experimental results are in good agreemen...Continue Reading

References

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Citations

Aug 12, 2020·Lab on a Chip·Zhengxin LiXuehua Zhang
Feb 20, 2021·Physical Review. E·Saptarshi BasuJoita Chakraborty
Aug 14, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Xiaolai LiDetlef Lohse
Jul 4, 2019·ACS Applied Materials & Interfaces·Lei BaoXuehua Zhang
May 28, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Jiasheng QianXuehua Zhang

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Methods Mentioned

BETA
atomic force microscopy
confocal microscopy
AFM

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