Flow-induced platelet activation in components of the extracorporeal membrane oxygenation circuit

Scientific Reports
Gabriel FuchsLisa Prahl Wittberg

Abstract

Extracorporeal membrane oxygenation (ECMO) is used for rescue in severe respiratory and/or circulatory failure. The patient's blood is pumped over artificial surfaces in the ECMO circuit. A platelet activation model was applied to study the potential thrombogenicity of ECMO circuit components: the centrifugal blood pump, cannulae, and tubing connectors. Based on the accumulated effect of the scalar form of the stress acting on the platelet over time, the activation model enables assessment of platelet activation and pinpoints regions of elevated activation risk in a component. Numerical simulations of the flow in different components of the ECMO circuit was carried out where the activation level is a function of the impact of local stress and its history along the path that the platelets follow. The results showed that the pump carried the largest risk for platelet activation followed by the reinfusion cannula and lastly the connectors. Pump thrombogenicity was mainly due to long residence time and high shear-rate while the connector showed a high level of non-stationary shear-rate that in turn may contribute to the formation of aggregates through direct platelet activation or through high shear-rate modulation of the vWF multi...Continue Reading

References

Apr 2, 2005·The Heart Surgery Forum·Juerg Peter MuellerMario Louis Lachat
Jan 22, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Matteo NobiliDanny Bluestein
Feb 5, 2010·Annals of Biomedical Engineering·D BluesteinK B Manning
Jan 30, 2013·Biomechanics and Modeling in Mechanobiology·João S SoaresDanny Bluestein
Sep 24, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Susan M HastingsShriprasad Deshpande
Dec 18, 2016·International Journal of Cardiology·Mark DennisUNKNOWN Sydney ECMO Research Interest Group
Apr 26, 2017·Annual Review of Biomedical Engineering·Lauren D C Casa, David N Ku

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Citations

Apr 11, 2019·Perfusion·Lars FalkLars Mikael Broman
Jun 4, 2019·Expert Review of Medical Devices·Deepika N Sarode, Shuvo Roy
Nov 7, 2019·Critical Care : the Official Journal of the Critical Care Forum·Sascha Gross-HardtChristian Karagiannidis
Mar 7, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jutta ArensRolf Rossaint
Aug 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jutta ArensRolf Rossaint
May 10, 2020·Critical Care : the Official Journal of the Critical Care Forum·Mariusz KowalewskiRoberto Lorusso
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Quanchao ZhangHonglin Luo
Feb 11, 2021·Journal of Clinical Medicine·Enrico SquiccimarroRoberto Lorusso
Mar 2, 2021·Frontiers in Bioengineering and Biotechnology·Julien LemétayerLisa Prahl Wittberg
May 11, 2021·Advanced Composites and Hybrid Materials·Ting HeZhaoliang Cui
Jun 13, 2021·Colloids and Surfaces. B, Biointerfaces·Quanchao ZhangHonglin Luo
Jun 3, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Francesco FiuscoLisa Prahl Wittberg

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

CentriMag
CCM +
STAR

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