Flow-induced segregation and dynamics of red blood cells in sickle cell disease.

Physical Review Fluids
Xiao ZhangMichael D Graham

Abstract

Blood flow in sickle cell disease (SCD) can substantially differ from normal blood flow due to significant alterations in the physical properties of the red blood cells (RBCs). Chronic complications, such as inflammation of the endothelial cells lining blood vessel walls, are associated with SCD, for reasons that are unclear. Here, detailed boundary integral simulations are performed to investigate an idealized model flow flow in SCD, a binary suspension of flexible biconcave discoidal fluid-filled capsules and stiff curved prolate capsules that represent healthy and sickle RBCs, respectively, subjected to pressure-driven flow in a planar slit. The stiff component is dilute. The key observation is that, unlike healthy RBCs that concentrate around the center of the channel and form an RBC-depleted layer (i.e. cell-free layer) next to the walls, sickle cells are largely drained from the bulk of the suspension and aggregate inside the cell-free layer, displaying strong margination. These cells are found to undergo a rigid-body-like rolling orbit near the walls. A binary suspension of flexible biconcave discoidal capsules and stiff straight (non-curved) prolate capsules is also considered for comparison, and the curvature of the st...Continue Reading

References

Dec 1, 1978·British Journal of Haematology·B E GladerD G Nathan
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D K KaulR L Nagel
Jun 1, 1989·The American Journal of Physiology·J C Firrell, H H Lipowsky
May 1, 1986·Biophysical Journal·M Bitbol
Mar 1, 1985·The American Journal of Physiology·G J TangelderR S Reneman
Nov 1, 1973·Zeitschrift Für Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie·W Helfrich
Oct 1, 1972·Microvascular Research·E Evans, Y C Fung
Mar 1, 1973·Biophysical Journal·R SkalakS Chien
Dec 1, 1973·The Journal of Clinical Investigation·P F Milner, S Charache
Mar 1, 1984·Microvascular Research·H L Goldsmith, S Spain
Dec 1, 1982·The American Journal of Physiology·I H Sarelius, B R Duling
Sep 11, 1997·The New England Journal of Medicine·H F Bunn
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M J Pearson, H H Lipowsky
Feb 15, 2002·Current Opinion in Hematology·Paul S Frenette
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tzung K HsiaiChih-Ming Ho
Feb 1, 2005·Analytical Chemistry·Sergey S ShevkoplyasMark W Bitensky
Aug 9, 2005·Journal of Biomechanics·Yi-Shuan J LiShu Chien
Apr 6, 2006·Journal of Internal Medicine·D G HarrisonC Searles
Nov 14, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Shu Chien
May 16, 2007·Physical Review Letters·Juan P Hernández-OrtizMichael D Graham
Mar 12, 2008·Annals of Biomedical Engineering·T AlMomaniK B Chandran
Sep 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Timo BetzCécile Sykes
Sep 22, 2009·PloS One·Abhishek Jain, Lance L Munn
Nov 4, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Dmitry A FedosovGeorge Em Karniadakis
Jul 30, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hong Zhao, Eric S G Shaqfeh
Feb 7, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Amit Kumar, Michael D Graham
Feb 14, 2012·Physical Review Letters·Dmitry A FedosovGerhard Gompper
Mar 10, 2012·Physical Review Letters·M Zurita-GotorE Wajnryb
Sep 12, 2012·Annals of Biomedical Engineering·Daniel A ReasorCyrus K Aidun
Sep 26, 2012·Physical Review Letters·Amit Kumar, Michael D Graham

❮ Previous
Next ❯

Citations

Jun 5, 2021·Biophysical Journal·Elahe JavadiSafa Jamali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.