PMID: 8950654Nov 1, 1996Paper

Flow input waveform effects on the temporal and spatial wall shear stress gradients in a femoral graft-artery connector

Journal of Biomechanical Engineering
C KleinstreuerJ P Archie

Abstract

Employing a validated finite volume code, a computer-aided design of the distal end of a femoral graft-artery junction has been considered to simulate transient three-dimensional blood flow for various flow input waveforms. The study relies on the hypothesis that large sustained wall shear stress gradients play a major role in the rapid recurrence of intimal hyperplasia plus atheroma after bypass surgery, leading to early graft failure. Two new dimensionless parameters have been introduced to correlate flow waveform characteristics with the severity of nonuniform hemodynamics and hence the potential risk for restenosis. The transient and, more importantly, the time-averaged wall shear stress gradient distributions shown, map out the junction areas which are still susceptible to restenosis, especially the toe region. Future geometric modifications will further reduce disturbed flow patterns and hence the probability of graft failure.

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Citations

Mar 18, 2005·Biomechanics and Modeling in Mechanobiology·Francesco Migliavacca, Gabriele Dubini
May 25, 2010·Annals of Biomedical Engineering·Foad KabinejadianYong Seng Tan
May 1, 2005·Journal of Biological Physics·Aike QiaoHu Zhao
Oct 24, 2001·Journal of Biomechanics·D LeeH Y Liang
Aug 1, 1997·Journal of Biomechanical Engineering·M LeiJ P Archie
Dec 15, 2007·Biomedical Engineering Online·Vijaya B KolachalamaPrasanth B Nair
Apr 12, 2014·Biomechanics and Modeling in Mechanobiology·Dibyendu SenguptaAlison L Marsden
Apr 7, 2007·Medical Engineering & Physics·Johannes V SoulisGeorge E Louridas
May 1, 2007·Medical Engineering & Physics·Jun-Mei ZhangYong Seng Tan
Nov 7, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M T WalshT McGloughlin
Nov 19, 2003·Journal of Biomechanical Engineering·P Worth Longest, Clement Kleinstreuer
Oct 17, 2001·Journal of Biomechanical Engineering·R S KeyntonS E Rittgers
Sep 21, 2005·Journal of Personality Assessment·Benjamin P Chapman, Bert Hayslip
Feb 19, 2002·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·C J BatesD Williams
Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·X BaoJ A Frangos
Oct 18, 2005·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·L P ChuaY S Tan

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