Flow invariant droplet formation for stable parallel microreactors

Nature Communications
Carson T RicheNoah Malmstadt

Abstract

The translation of batch chemistries onto continuous flow platforms requires addressing the issues of consistent fluidic behaviour, channel fouling and high-throughput processing. Droplet microfluidic technologies reduce channel fouling and provide an improved level of control over heat and mass transfer to control reaction kinetics. However, in conventional geometries, the droplet size is sensitive to changes in flow rates. Here we report a three-dimensional droplet generating device that exhibits flow invariant behaviour and is robust to fluctuations in flow rate. In addition, the droplet generator is capable of producing droplet volumes spanning four orders of magnitude. We apply this device in a parallel network to synthesize platinum nanoparticles using an ionic liquid solvent, demonstrate reproducible synthesis after recycling the ionic liquid, and double the reaction yield compared with an analogous batch synthesis.

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Citations

Jan 17, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Sandra JendrzejStephan Barcikowski
Jun 7, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Joshua S SantanaSara E Skrabalak
Apr 22, 2016·Lab on a Chip·Nirveek BhattacharjeeAlbert Folch
Nov 4, 2017·Lab on a Chip·Liang-Jun PanZhi-Ling Zhang
Jul 27, 2018·Lab on a Chip·Ming LiDino Di Carlo
Aug 16, 2019·Physical Chemistry Chemical Physics : PCCP·Mark-Robert KalusBilal Gökce
Nov 7, 2019·Micromachines·Jia Ming ZhangHuiling Duan
Mar 4, 2020·Chemical Communications : Chem Comm·Lu WangNoah Malmstadt
Aug 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Koki Kamiya, Shoji Takeuchi
Nov 15, 2018·Micromachines·Marek WojnickiKrzysztof Fitzner
May 10, 2019·Microsystems & Nanoengineering·Chaowei WangKoji Sugioka
Apr 4, 2021·Micromachines·Nafisat GyimahTamas Pardy
Apr 6, 2021·Environmental Science. Nano·Alba García-RodríguezGretchen J Mahler
May 27, 2021·Scientific Reports·Cyrille L Delley, Adam R Abate
Nov 4, 2017·Journal of the American Chemical Society·Ming ZhangHengquan Yang
May 26, 2017·Chemical Reviews·Luoran ShangYuanjin Zhao
Jul 10, 2019·ACS Applied Materials & Interfaces·Emily J RobertsRichard L Brutchey
Jan 1, 2018·Journal of Molecular Biology·Jérôme CharmetTuomas P J Knowles

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Methods Mentioned

BETA
chip
Prototyping
scanning electron microscopy
X-ray
nuclear magnetic resonance
chips
NMR

Software Mentioned

FineLine Prototyping
Matlab
SynQuest
ProEngineer

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