Flow-mediated dilatation of the brachial artery and left ventricular geometry in hypertensive patients

Journal of Hypertension
M L MuiesanE Agabiti-Rosei

Abstract

In arterial hypertension, the spectrum of geometric patterns in the left ventricle may parallel the structural alterations detected in the carotid arteries and in subcutaneous small arteries. It has been also reported that hypertensive left ventricular hypertrophy (LVH) may be associated with endothelial dysfunction, as evaluated by the response of coronary or forearm vasculature to acetylcholine infusion. The aim of this study was to evaluate the flow-mediated vasodilatation (FMD) of the brachial artery, non-invasive estimate of endothelium-dependent vasodilatation according to left ventricular geometric adaptations in hypertensive patients. In 16 normotensive (nine males, seven females, aged 40-68 years) and in 78 hypertensive subjects (50 males, 28 females, aged 42-67 years), we performed an echocardiographic study for the measurement of left ventricular mass index (LVMI) and relative wall thickness (RWT); we measured to a high resolution the brachial artery diameter at rest, during reactive hyperaemia (5 min of brachial artery occlusion) and after sublingual glyceril trinitrate (GTN); brachial artery flow velocity was measured by pulsed Doppler. Twenty-six hypertensive patients had a normal LVMI (LVMI < 51 g/ m2.7) and geom...Continue Reading

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Citations

Oct 17, 2001·Current Atherosclerosis Reports·S G West
May 28, 2003·Journal of the American College of Cardiology·Gary D PlotnickJohn A Wise
Mar 6, 2009·Journal of Human Hypertension·J-Z XuP-J Gao
Apr 6, 2016·Thrombosis Research·Nikolaos SousosVasileia Garipidou
Mar 30, 2011·Atherosclerosis·Dick H J ThijssenDaniel J Green
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alaattin YildizMehmet S Sever
Mar 13, 2014·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Lorenzo GhiadoniStefano Taddei
May 31, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·N M BreetveldM E A Spaanderman
Jul 16, 2008·Journal of Hypertension·M Lorenza MuiesanEnrico Agabiti-Rosei
Oct 20, 2009·Journal of Hypertension·Eugenia GkaliagkousiAlbert Ferro
Dec 4, 2003·Coronary Artery Disease·Ertugrul ErcanIstemi Nalbantgil
Sep 16, 2015·Current Hypertension Reports·Eugenia GkaliagkousiStella Douma
Feb 12, 2020·Journal of Human Hypertension·Francesca CorteseMarco Matteo Ciccone
May 17, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Daniel H CraigheadLacy M Alexander
Dec 5, 2003·Journal of Hypertension·Enzo PorteriEnrico Agabiti Rosei
Jul 17, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Eleni GavriilakiAchilles Anagnostopoulos

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