Flow-mediated vasodilation and endothelium function in children with postural orthostatic tachycardia syndrome

The American Journal of Cardiology
Ying LiaoJun-bao Du

Abstract

The study was designed to explore flow-mediated vasodilation (FMD) and endothelium function in children with postural orthostatic tachycardia syndrome (POTS). The patient group consisted of 46 children 12 +/- 3 years of age who were diagnosed with POTS from June 2008 to January 2009 by head-up test or head-up tilt test at Peking University First Hospital. Twenty healthy children 12 +/- 4 years of age were selected for the control group. Plasma concentrations of nitric oxide (NO) and activity of NO synthase (NOS) were determined in the patient and control groups. FMD of each participant's brachial artery was measured using color Doppler vascular ultrasound and a comparison of FMDs and plasma NO and NOS activities between the 2 groups was done using independent t test. No significant differences were found between the POTS and control groups in age, sex ratio, height, body weight, baseline blood pressure, heart rate, and baseline brachial artery diameter. Patients in the POTS group had larger FMD (10.8 +/- 4.4%) than children in the control group (5.7 +/- 2.2%), and this difference was significant (p <0.01). Plasma NO and NOS levels were significantly higher in the POTS group than in the control group (NO 74 +/- 19 micromol/L in ...Continue Reading

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Citations

May 31, 2013·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Imad T Jarjour, Laila K Jarjour
Jul 6, 2014·Annals of Vascular Diseases·Eisuke AmiyaIssei Komuro
Sep 15, 2016·Chinese Medical Journal·Wen-Rui XuJun-Bao Du
Nov 21, 2014·Expert Review of Cardiovascular Therapy·Artur Z Pietrucha
Feb 8, 2018·World Journal of Pediatrics : WJP·Wei BaiJun-Bao Du
Nov 28, 2017·Chinese Medical Journal·Ying LiaoJun-Bao Du
Sep 28, 2017·Chinese Medical Journal·Wen-Rui XuJun-Bao Du
Nov 9, 2019·European Journal of Applied Physiology·Erika IwamotoShigehiko Ogoh
May 15, 2020·World Journal of Pediatrics : WJP·Hong-Xia LiYue Yuan
Jun 15, 2013·Journal of Applied Physiology·Colleen T Ives, Kurt Kimpinski
Dec 19, 2018·Frontiers in Pediatrics·Yaqi LiHongfang Jin
Sep 29, 2020·Frontiers in Immunology·Yaru WangYing Liao
Feb 6, 2020·World Journal of Pediatrics : WJP·Yuan-Yuan WangHong-Fang Jin
Mar 11, 2021·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Emily C SmithAlfredo Gamboa

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