PMID: 2490093Jan 1, 1989Paper

Flow microcalorimetric assay of antibiotics--I. Polymyxin B sulphate and its combinations with neomycin sulphate and zinc bacitracin on interaction with Bordetella bronchiseptica (NCTC 8344)

Journal of Pharmaceutical and Biomedical Analysis
N Joslin KjeldsenR J Miles

Abstract

A flow microcalorimetric assay for polymyxin B sulphate has been developed which has a better reproducibility (relative standard deviation less than 3%) and sensitivity (0.35 micrograms ml-1) than conventional microbiological assays, and requires an assay time of ca. 4.5 h. The combinations with zinc bacitracin, with neomycin sulphate, and with both zinc bacitracin and neomycin sulphate indicate antagonism between these antibiotics upon interaction with Bordetella bronchiseptica (NCTC 8344). The combinations of all three antibiotics assayed were: (1) equimolar proportions; and (2) those proportions present in the commercial preparation TrisepR (ICI, Macclesfield, UK).

References

Nov 1, 1975·Journal of General Microbiology·D Greenwood
Mar 24, 1972·Biochemical and Biophysical Research Communications·T M Chapman, M R Golden
Apr 9, 1974·Biochemistry·R E GalardyM P Printz
Feb 20, 1964·The New England Journal of Medicine·D N MACKAY, D KAYE
May 29, 1964·Science·L C CRAIG

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