PMID: 2490095Jan 1, 1989Paper

Flow microcalorimetric assay of antibiotics--III. Zinc bacitracin and its combinations with polymyxin B sulphate and neomycin sulphate on interaction with Micrococcus luteus

Journal of Pharmaceutical and Biomedical Analysis
N Joslin KjeldsenR J Miles

Abstract

A flow microcalorimetric assay for zinc bacitracin has been developed which has better reproducibility (relative standard deviation less than 2%) and sensitivity (0.02 micrograms ml-1) than conventional microbiological assays, and requires an assay time of between 7.5-9 h. The assay is not suitable for zinc bacitracin determinations in the presence of equimolar concentrations of polymyxin B sulphate or neomycin sulphate, or of these antibiotics in the proportions in which they occur in the commercial preparation Trisep (ICI, Macclesfield, UK).

References

Feb 6, 1976·Biochimica Et Biophysica Acta·U B SleytrK J Thorne
Oct 1, 1974·Postgraduate Medical Journal·A C Baird-Parker
Nov 1, 1972·Canadian Journal of Microbiology·R J Paulton
Mar 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·G Siewert, J L Strominger

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