Flow of a circulating tumor cell and red blood cells in microvessels

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Naoki TakeishiTakuji Ishikawa

Abstract

Quantifying the behavior of circulating tumor cells (CTCs) in the blood stream is of fundamental importance for understanding metastasis. Here, we investigate the flow mode and velocity of CTCs interacting with red blood cells (RBCs) in various sized microvessels. The flow of leukocytes in microvessels has been described previously; a leukocyte forms a train with RBCs in small microvessels and exhibits margination in large microvessels. Important differences in the physical properties of leukocytes and CTCs result from size. The dimensions of leukocytes are similar to those of RBCs, but CTCs are significantly larger. We investigate numerically the size effects on the flow mode and the cell velocity, and we identify similarities and differences between leukocytes and CTCs. We find that a transition from train formation to margination occurs when (R-a)/t(R)≈1, where R is the vessel radius, a is the cell radius, and t(R) is the thickness of RBCs, but that the motion of RBCs differs from the case of leukocytes. Our results also show that the velocities of CTCs and leukocytes are larger than the average blood velocity, but only CTCs move faster than RBCs for microvessels of R/a≈1.5-2.0. These findings are expected to be useful not o...Continue Reading

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Citations

Oct 16, 2016·Biomechanics and Modeling in Mechanobiology·L L XiaoB M Fu
Apr 21, 2018·International Journal of Molecular Sciences·Shike WangRen Xu
Jun 5, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Naoki TakeishiTakuji Ishikawa
Feb 28, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Achim Guckenberger, Stephan Gekle
May 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Anerudh KannanAlbert Siryaporn
Nov 30, 2019·Nature Reviews. Cancer·Gautier FollainJacky G Goetz
Jul 16, 2020·Scientific Reports·Mohammad Nooranidoost, Ranganathan Kumar
Mar 25, 2019·Micromachines·Naoki TakeishiShigeo Wada
Jul 16, 2017·Scientific Reports·Naoki Takeishi, Yohsuke Imai
Feb 9, 2021·ACS Biomaterials Science & Engineering·Jyotsana PriyadarshaniSuman Chakraborty
Feb 20, 2021·PLoS Computational Biology·Sitong WangHuixin Shi
Jul 23, 2020·Biophysical Journal·Scott J HymelDamir B Khismatullin
Mar 26, 2021·Biomechanics and Modeling in Mechanobiology·Daniel F PuleriAmanda Randles

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