Flow variability and its physical causes in infusion technology: a systematic review of in vitro measurement and modeling studies

Biomedizinische Technik. Biomedical Engineering
Roland A SnijderAnnemoon M Timmerman

Abstract

Infusion therapy is medically and technically challenging and frequently associated with medical errors. When administering pharmaceuticals by means of infusion, dosing errors can occur due to flow rate variability. These dosing errors may lead to adverse effects. We aimed to systematically review the available biomedical literature for in vitro measurement and modeling studies that investigated the physical causes of flow rate variability. Special focus was given to syringe pump setups, which are typically used if very accurate drug delivery is required. We aimed to extract from literature the component with the highest mechanical compliance in syringe pump setups. We included 53 studies, six of which were theoretical models, two articles were earlier reviews of infusion literature, and 45 were in vitro measurement studies. Mechanical compliance, flow resistance, and dead volume of infusion systems were stated as the most important and frequently identified physical causes of flow rate variability. The syringe was indicated as the most important source of mechanical compliance in syringe pump setups (9.0×10-9 to 2.1×10-8 l/Pa). Mechanical compliance caused longer flow rate start-up times (from several minutes up to approximate...Continue Reading

References

Jul 1, 1997·Journal of Vascular and Interventional Radiology : JVIR·J F AngleC J Tegtmeyer
Jul 20, 1999·Paediatric Anaesthesia·D W Kim, D J Steward
Apr 26, 2000·Anaesthesia·C McCarrollR Taylor
Oct 14, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M WeissJ Fischer
Apr 3, 2001·Ophthalmic Plastic and Reconstructive Surgery·C W EifrigA G Neff
Jun 26, 2001·Acta Anaesthesiologica Scandinavica·M WeissO Baenziger
Sep 28, 2001·British Journal of Anaesthesia·H KernW J Kox
Nov 7, 2001·Paediatric Anaesthesia·T NeffM Weiss
Mar 23, 2005·Anesthesia and Analgesia·Mark A LovichRobert A Peterfreund
Mar 25, 2005·Paediatric Anaesthesia·A DönmezZ Kayhan
Dec 17, 2005·Injury·Naga V G Jayanthi, Harshad V Dabke
Mar 23, 2007·European Journal of Anaesthesiology·M GuillierB Allaouchiche
Sep 4, 2008·Critical Care Medicine·Roy IlanEdward E Etchells
Sep 19, 2009·Anesthesia and Analgesia·Bertrand DécaudinPascal Odou
Nov 26, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Nadia SchmidtAndrés Maturana
Jan 14, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Daniel S LeviGreg Carman
Mar 25, 2010·Anesthesia and Analgesia·Robert S Murphy, Steven J Wilcox
Mar 15, 2011·The Journal of Hospital Infection·B EllgerA W Friedrich
May 28, 2011·Pharmaceutical Development and Technology·Yoshinori Kawabata
Jun 21, 2012·Paediatric Anaesthesia·Amy C TsaoRobert A Peterfreund
Oct 13, 2012·Paediatric Anaesthesia·Anne C van der EijkBert J Smit
Jan 30, 2013·The Journal of Pharmacy and Pharmacology·Natalie J MedlicottRoland S Broadbent
Jun 7, 2013·Korean journal of anesthesiology·Jong-Yeop KimSang-Kee Min
Aug 13, 2013·European Journal of Pediatrics·Mehdi OualhaFabrice Lesage
Nov 8, 2013·Journal of Medical Engineering & Technology·Won Hee SeoByoung Gook Loh
Dec 21, 2013·Anesthesia and Analgesia·Elie Sarraf, Jeff E Mandel
Feb 1, 2014·Archives of Disease in Childhood·Catherine M T SherwinRoland S Broadbent
May 13, 2014·Journal of Neonatal-perinatal Medicine·A C van der EijkB J Smit
May 16, 2014·Anesthesiology and Pain Medicine·Masood Mohseni, Amin Ebneshahidi
Aug 21, 2014·Regional Anesthesia and Pain Medicine·Robyn S WeismanRalf E Gebhard
May 7, 2015·Biomedizinische Technik. Biomedical Engineering·Elsa BatistaAnnemoon Timmerman

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Citations

Nov 30, 2016·A & a Case Reports·Roland A SnijderAnnemoon M D E Timmerman
Jul 13, 2019·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Marc BlancherDamien Viglino
Nov 8, 2020·Journal of Clinical Monitoring and Computing·Kwan Young HongJeong-Jin Min
Mar 20, 2021·AACN Advanced Critical Care·Jeannine W C BlakeKaren K Giuliano

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