FLT3: receptor and ligand

Growth Factors
Hans G Drexler, Hilmar Quentmeier

Abstract

FLT3 is a receptor tyrosine kinase (RTK) expressed by immature hematopoietic progenitor cells. The ligand for FLT3 is a transmembrane or soluble protein and is expressed by a variety of cells including hematopoietic and marrow stromal cells; in combination with other growth factors, the ligand stimulates proliferation and development of stem cells, myeloid and lymphoid progenitor cells, dendritic cells and natural killer cells. Activation of the receptor leads to tyrosine phosphorylation of various key adaptor proteins known to be involved in different signal transduction pathways that control proliferation, survival and other processes in hematopoietic cells. FLT3 is not only of utmost interest regarding physiological processes of hematopoietic cells but also with regard to pathological aspects, namely leukemogenesis and diagnosis, prognosis and therapy of leukemia. Activating mutations of the receptor have been recognized as the most common genetic abnormality in acute myeloid leukemia (AML), occurring in about 30% of adult cases. AML patients with FLT3 mutations tend to have a poor prognosis, thus FLT3 is an attractive target of therapy, for instance using kinase inhibitors.

Citations

Feb 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bilal B AyachPeter P Liu
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed L SalemDavid J Cole
Mar 12, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Kenneth VerstraeteSavvas N Savvides
Jun 10, 2016·Journal of Clinical Periodontology·Sabrina Rebollo ZaniRicardo Palmier Teles
Sep 6, 2019·Science Translational Medicine·Katelyn MelgarDaniel T Starczynowski
Dec 7, 2007·Journal of Cellular and Molecular Medicine·Jian-Xin Gao
Jan 30, 2010·Leukemia·E VoissetP De Sepulveda
May 28, 2013·Genome Génome / Conseil National De Recherches Canada·Howard WongRandal N Johnston
Aug 10, 2011·Clinical & Developmental Immunology·Afton L Thompson, Herman F Staats
Dec 5, 2018·Scientific Reports·Lucas GutierrezHouda Alachkar
Jan 16, 2008·Expert Opinion on Biological Therapy·Thomas E IchimWei-Ping Min
Jun 28, 2006·Growth Factors·Margaret L Hibbs, Kenneth W Harder
May 14, 2009·International Journal of Radiation Biology·Frank J Papatheofanis, Mohammad M Najib
Jan 1, 2014·Journal of Clinical Medicine·Caroline Benedicte Nitter EngenBjørn Tore Gjertsen
Jul 22, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Edina SilajdžićOskar Hansson
Oct 16, 2014·British Journal of Haematology·Gaetane Nocturne, Xavier Mariette
Dec 17, 2014·Protein & Cell·Xiaoguang Wang, Delong Meng
Mar 15, 2011·Annals of Neurology·Min ShiJing Zhang
Aug 12, 2016·Turkish Journal of Medical Sciences·Muammer Merve AydinKamil Can Akçali
Jan 22, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Grace E WeberLynn M Bekris
Oct 21, 2020·Leukemia & Lymphoma·Pierre PeterlinMatthew Collin

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