PMID: 8950555Oct 1, 1996Paper

Fluconazole monotherapy for cryptococcosis in non-AIDS patients

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
H YamaguchiS Kohno

Abstract

Treatment with 200 to 400 mg/day fluconazole was evaluated in 44 patients without AIDS who had cryptococcosis (19 with cryptococcal meningitis, 22 with pulmonary cryptococcosis, 3 with other cryptococcal infections). For all patients, the clinical response rate was 89% (48% were clinically cured and 41% clinically improved). Of the patients with cryptococcal meningitis, 89% were mycologically cured. These rates are comparable to those obtained in the treatment of AIDS patients with cryptococcal disease. In the group of patients with cryptococcal meningitis, there was a high rate of agreement between the mycological response to therapy and cryptococcal antigen test results. The use of cryptococcal antigen testing is recommended in all patients with cryptococcosis.

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Citations

Jun 17, 2005·European Journal of Pediatrics·Masayoshi ShinjohTakao Takahashi
Nov 30, 2000·Current Infectious Disease Reports·A R Tunkel
Oct 3, 2009·Epidemiology and Infection·Y-M ChuangP R Hsueh
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