PMID: 9417515Jan 1, 1997Paper

Fluconazole-resistant Candida species from HIV infected patients with recurrent Candida stomatitis: cross resistance to itraconazole and ketoconazole

Mycoses
S Metzger, H Hofmann

Abstract

In vitro susceptibility to fluconazole of Candida species isolated from 83 HIV-infected patients treated with fluconazole because of recurrent Candida stomatitis was monitored over a period of two years. A microdilution assay with high-resolution antifungal assay (HR) medium and RPMI 1640-medium were compared. In vitro less susceptible and fluconazole resistant C. species were observed in 23 patient at the end of the study. The Candida isolates recovered from oral rinsing fluids at the beginning and the end of study were tested for crossresistance to itraconazole and ketoconazole. Susceptibility to ketoconazole and to itraconazole was reduced using RPMI 1640-medium. Susceptibility of the isolates to fluconazole was not influenced by the assay medium. In 21 patients in vitro fluconazole resistant or less susceptible C. albicans were observed. 9 of 21 isolates showed crossresistance to itroconazole and ketoconazole, in 10 isolates only crossresistance to itraconazole was observed. During fluconazole treatment double infections due to combination of C. albicans and C. glabrata or C. krusei increased from 20% to 78% C. krusei was resistant to the three azoles. C. glabrata was less susceptible (4-8 mg/l) or resistant (> 8 mg/l) to f...Continue Reading

References

Oct 1, 1992·Journal of Medical Microbiology·D W Warnock
Sep 1, 1992·Antimicrobial Agents and Chemotherapy·M A PfallerD W Warnock
Dec 11, 1992·Journal of Clinical Microbiology·A Espinel-IngroffM G Rinaldi
Dec 1, 1992·Antimicrobial Agents and Chemotherapy·H vanden BosscheM C Coene
Nov 1, 1991·The Journal of Infection·D SmithB Gazzard
Nov 1, 1991·Antimicrobial Agents and Chemotherapy·P Fan-HavardR H Eng
Jul 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M AkovaD Gür
Mar 1, 1991·The Journal of Infection·R FoxB K Mandal
Mar 1, 1991·The Journal of Infection·V S KitchenJ R Harris
Oct 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S L NewmanK Vigilante
Oct 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A White, M B Goetz
Mar 1, 1994·The Journal of Infection·P F Troke, C A Hitchcock
Jun 1, 1994·AIDS·G G BailyB K Mandal
Dec 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D J BokenM G Rinaldi
Feb 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S ReddingM Pfaller
Oct 1, 1993·Clinical Microbiology Reviews·J H RexJ N Galgiani
Jan 1, 1993·Antimicrobial Agents and Chemotherapy·R A FromtlingG D Roberts
Mar 1, 1993·The Journal of Infection·T T Ng, D W Denning
Apr 1, 1993·Antimicrobial Agents and Chemotherapy·F C Odds
Apr 1, 1993·The Journal of Antimicrobial Chemotherapy·F C Odds
Jan 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C QueredaF Baquero
Feb 1, 1996·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·B TebbeC E Orfanos

❮ Previous
Next ❯

Citations

Mar 20, 1999·Current Opinion in Pediatrics·T LehrnbecherS J Chanock
Mar 15, 2005·Scandinavian Journal of Infectious Diseases·Erja ChryssanthouMagnus Björkholm
May 5, 2006·Advances in Dental Research·M M CooganL P Samaranayake
Jan 30, 2007·Letters in Applied Microbiology·Y Rukayadi, J-K Hwang
Apr 5, 2005·Scandinavian Journal of Infectious Diseases·Lars StolleJohnny Keller
Mar 21, 2002·The Lancet Infectious Diseases·Dominique Sanglard, Frank C Odds
Nov 20, 2004·Phytotherapy Research : PTR·Seungwon Shin, Mi-Sun Pyun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.