PMID: 8970221Dec 1, 1996Paper

Fluconazole vs. amphotericin B for the treatment of neonatal fungal septicemia: a prospective randomized trial

The Pediatric Infectious Disease Journal
M DriessenF P De Villiers

Abstract

Fungal septicemia is a devastating disease in the neonate, especially in the low birth weight preterm infant who is especially vulnerable to disseminated fungal sepsis. The objective of this study was to compare the efficacy, safety and overall convenience of fluconazole vs. amphotericin B for the treatment of disseminated fungal sepsis in neonates. A prospective, randomized, collaborative study conducted at two South African neonatal units. Twenty-four infants with proven fungal septicemia were treated from June, 1992, to June, 1993. Twelve received fluconazole, 11 received amphotericin B and 1 was excluded. Assessment of hepatic, renal and hematologic functions were performed before, during and after treatment. The two groups were comparable at the time of enrollment into the study. Infants receiving amphotericin B had significantly higher values of total and direct bilirubin and alkaline phosphatase values at the end of treatment, while the fluconazole group showed a significant increase in the platelet count. The cumulative total numbers of days receiving intravenous therapy for the administration of antifungal drugs were 57 for the fluconazole group and 162 for the amphotericin group; no central lines were needed in the fl...Continue Reading

References

Jan 1, 1992·Scandinavian Journal of Infectious Diseases·S BodéK Hjelt
Jun 1, 1992·The Journal of Pediatrics·J W LeeT J Walsh
Feb 1, 1991·Antimicrobial Agents and Chemotherapy·C ViscoliA Terragna
Mar 1, 1990·Reviews of Infectious Diseases·K W BrammerJ K Faulkner
Mar 1, 1990·Reviews of Infectious Diseases·A M SugarB Dupont
Jan 1, 1990·The Pediatric Infectious Disease Journal·K M ButlerC J Baker
Jul 1, 1989·Diagnostic Microbiology and Infectious Disease·H Ikemoto
Oct 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C ViscoliA Terragna
May 1, 1987·Annals of Internal Medicine·B Dupont, E Drouhet
Jan 17, 1980·The New England Journal of Medicine·G Medoff, G S Kobayashi
Jul 1, 1993·The Journal of Pediatrics·S EpelbaumC Piussan
Aug 1, 1964·Annals of Internal Medicine·W T BUTLERG J HILL
Aug 1, 1964·Annals of Internal Medicine·J P UTZ
Aug 1, 1964·Annals of Internal Medicine·M W BRANDISS

❮ Previous
Next ❯

Citations

Jan 18, 2013·European Journal of Clinical Pharmacology·Oluwaseun EgunsolaHelen Sammons
Jul 27, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·K ReinhartK Werdan
Apr 19, 2006·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Roni K Devlin
May 15, 2013·International Journal of Antimicrobial Agents·Jad ChahoudSouha S Kanj
Jul 8, 1999·Mycoses·R SchwarzeL Pittrow
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C J FichtenbaumW G Powderly
Dec 31, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN Infectious Diseases Society of America
Aug 1, 1997·The Pediatric Infectious Disease Journal·S WainerA Akierman
Aug 26, 1999·The Pediatric Infectious Disease Journal·L G RobinsonA P Kourtis
Jan 25, 2003·Current Opinion in Pediatrics·Rachel L Chapman
Nov 30, 2006·The Pediatric Infectious Disease Journal·Gloria P HeresiGregory L Kearns
Aug 6, 2008·The Pediatric Infectious Disease Journal·Flavio Queiroz-TellesUNKNOWN Micafungin Invasive Candidiasis Study Group
Dec 23, 2011·The Pediatric Infectious Disease Journal·Simon B AscherCassandra Moran
Jul 20, 2004·Clinical Microbiology Reviews·David Kaufman, Karen D Fairchild
Apr 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·T Duke
Apr 23, 2004·Drugs·Daniel A C FrattarelliJacob V Aranda
Oct 12, 2007·Paediatric Drugs·Benito Almirante, Dolors Rodríguez
Nov 30, 2013·Pharmaceutical Research·B Maria AlphonsaR Jayakumar
Apr 7, 2015·Expert Opinion on Pharmacotherapy·Lorena Botero-CalderonMichael Cohen-Wolkowiez
Jan 10, 2012·Expert Opinion on Pharmacotherapy·Hasan TezerUğur Dilmen
Dec 19, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasJack D Sobel
Jun 15, 2013·Revista iberoamericana de micología·María E SantolayaUNKNOWN Grupo Proyecto Épico
Jun 13, 2013·Revista iberoamericana de micología·María E SantolayaUNKNOWN Latin America Invasive Mycosis Network
Nov 28, 2012·Seminars in Perinatology·Nidhi TripathiDaniel K Benjamin
Apr 5, 2011·Enfermedades infecciosas y microbiología clínica·José María AguadoUNKNOWN Grupo de Estudio de Micología Médica de la SEIMC (GEMICOMED)
Feb 5, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S Nouri-MerchaouiH Seboui
Sep 9, 2008·Mayo Clinic Proceedings·Anat Gafter-GviliMical Paul
Feb 24, 2007·Seminars in Perinatology·Rachel L Chapman
Sep 21, 2006·Infectious Disease Clinics of North America·William J Steinbach, Thomas J Walsh
Dec 16, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Hasan CetinNilgun Kultursay
Feb 11, 2012·Pediatrics International : Official Journal of the Japan Pediatric Society·Solmaz CelebiBeyza Ener
Oct 12, 2005·Archives of Medical Research·Charles R SimsJohn H Rex
Aug 17, 2005·Infectious Disease Clinics of North America·P Brian SmithDaniel K Benjamin
Jul 9, 2005·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·P Brian SmithDaniel K Benjamin
Jun 1, 2005·Pediatric Clinics of North America·William J Steinbach
Oct 29, 2014·Mycoses·Athanasios TragiannidisAndreas H Groll
Oct 13, 2007·Expert Opinion on Pharmacotherapy·Christine C ChiouAndreas H Groll
Aug 10, 2005·Expert Opinion on Pharmacotherapy·Kenneth F TiffanyDaniel K Benjamin
Dec 2, 2008·Expert Opinion on Pharmacotherapy·Ioanna FiliotiEmmanuel Roilides
Feb 14, 2015·Clinics in Perinatology·Kelly C Wade, Heather M Monk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Sabrina GoudjilTaieb Chouaki
© 2021 Meta ULC. All rights reserved