Fluctuating expression of microRNAs in adenovirus infected cells

Virology
Hongxing ZhaoUlf Pettersson

Abstract

The changes in cellular microRNA (miRNA) expression during the course of an adenovirus type 2 infection in human lung fibroblast were studied by deep RNA sequencing. Expressions of 175 miRNAs with over 100 transcripts per million nucleotides were changed more than 1.5-fold. The expression patterns of these miRNAs changed dramatically during the course of the infection, from upregulation of the miRNAs known as tumor suppressors (such as miR-22, miR-320, let-7, miR-181b, and miR-155) and down-regulation of oncogenic miRNAs (such as miR-21 and miR-31) early to downregulation of tumor suppressor miRNAs (such as let-7 family, mir-30 family, 23/27 cluster) and upregulation of oncogenic miRNAs (include miR-125, miR-27, miR-191) late after infection. The switch in miRNA expression pattern occurred when adenovirus DNA replication started. Furthermore, deregulation of cellular miRNA expression was a step-wise and special sets of miRNAs were deregulated in different phases of infection.

References

Oct 23, 1997·Genome Research·S Audic, J M Claverie
Jan 1, 1997·Annual Review of Genetics·J Flint, T Shenk
Aug 18, 2001·Cell·M FuchsD M Livingston
Mar 16, 2005·Cell·Steven M JohnsonFrank J Slack
Jun 10, 2005·Nature·Kathryn A O'DonnellJoshua T Mendell
Jul 19, 2005·Cancer Research·Jennifer A ChanKenneth S Kosik
Aug 17, 2005·Cancer Research·Marilena V IorioCarlo M Croce
Sep 22, 2005·Genes, Chromosomes & Cancer·Jinmai JiangThomas D Schmittgen
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Aug 23, 2006·Journal of Cellular Biochemistry·Huban KutayKalpana Ghoshal
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ryan M O'ConnellDavid Baltimore
Mar 21, 2007·Virology·Hongxing ZhaoUlf Pettersson
Apr 4, 2007·Oncogene·J L MottG J Gores
Sep 21, 2007·Journal of Virology·Rebecca L SkalskyRolf Renne
Dec 14, 2007·Nature·Eva GottweinBryan R Cullen
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Srikumar SenguptaPaul Ahlquist
Jun 11, 2008·Cell Host & Microbe·Eva Gottwein, Bryan R Cullen
Aug 5, 2008·Cancer Research·Troels SchepelerClaus L Andersen
Oct 3, 2008·Cancer Research·Thales PapagiannakopoulosKenneth S Kosik
Oct 24, 2008·Journal of Virology·Yuguang ZhaoVenugopal Nair
Dec 20, 2008·Nucleic Acids Research·Zhumur GhoshJayprokas Chakrabarti
Jan 13, 2009·Experimental Hematology·Dale G SchaarYi Ting
Jan 23, 2009·Journal of Neuro-oncology·Alfredo ContiFrancesco Tomasello
Feb 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mohit SachdevaYin-Yuan Mo
Feb 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tsung-Cheng ChangJoshua T Mendell
Feb 28, 2009·EMBO Reports·Christoph A GebeshuberJavier Martinez
Mar 10, 2009·Biochimica Et Biophysica Acta·Isabella FaraoniEnzo Bonmassar
Mar 19, 2009·Genes & Development·Minh T N LeBing Lim
Oct 6, 2009·Journal of Gastroenterology·Zhen JiangYuanyuan Zhang

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Citations

Jun 28, 2015·Virus Research·Virginia K Vachon, Graeme L Conn
Jul 5, 2016·Reviews in Medical Virology·Alireza TahamtanVahid Salimi
Dec 14, 2016·Journal of Proteome Research·Hongxing ZhaoSara Bergström Lind
Sep 27, 2018·PloS One·Alberto ValdésSara Bergström Lind
May 31, 2019·Upsala Journal of Medical Sciences·Ulf Pettersson
Dec 8, 2019·FEBS Letters·Hongxing ZhaoUlf Pettersson
Feb 8, 2020·Proteomics·Alberto ValdésSara Bergström Lind
Jul 21, 2017·Frontiers in Oncology·Xavier Bofill-De RosCristina Fillat
Jan 9, 2019·Frontiers in Microbiology·Gregory D PooreEphraim L Tsalik
Aug 5, 2017·Frontiers in Microbiology·Diogo Piedade, José M Azevedo-Pereira
May 18, 2021·Frontiers in Pediatrics·Zhi LiuDongchi Zhao

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