Apr 13, 2020

Fluctuation relations and fitness landscapes of growing cell populations

BioRxiv : the Preprint Server for Biology
Arthur Genthon, D. Lacoste

Abstract

We construct a pathwise formulation of a growing population of cells, based on two different samplings of lineages within the population, namely the forward and backward samplings. We show that a general symmetry relation, called fluctuation relation relates these two samplings, independently of the model used to generate divisions and growth in the cell population. Known models of cell size control are studied with a formalism based on path integrals or on operators. We investigate some consequences of this fluctuation relation, which constrains the distributions of the number of cell divisions and leads to inequalities between the mean number of divisions and the doubling time of the population. We finally study the concept of fitness landscape, which quantifies the correlations between a phenotypic trait of interest and the number of divisions. We obtain explicit results when the trait is the age or the size, for age and size-controlled models.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Carbon
Adenoma
Oxidation
Proteomics
Proteome
Colorectal Cancer Pathway
Microbial
Description
Tributyl phosphate
Feces

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

The Chronicle of Higher Education
Richard Monastersky
The Australian and New Zealand Journal of Surgery
G L Newstead
The Australian and New Zealand Journal of Surgery
I Faris
© 2020 Meta ULC. All rights reserved