PMID: 6986736Jan 1, 1980Paper

Fludrocortisone suppression test in normal subjects, in patients with essential hypertension and in patients with various forms of aldosteronism

Acta Endocrinologica
J O Lund, M D Nielsen

Abstract

The response of urinary diurnal tetrahydroaldosterone (TH-aldo) excretion for fluodrocortisone administration (0.3 mg q.i.d. for 3 days) was studied. In normal subjects (n = 13) and in patients with essential hypertension (n = 8), urinary TH-aldo decreased to 36 per cent (range 19-48) and to 51 per cent (range 33-61) of the control value, respectively. Twenty-four patients with primary aldosteronism were studied. Twenty-two of these showed no significant suppression of urinary TH-aldo in that the excretion of TH-aldo was 79 per cent of the control value or more. Nineteen of these patients were submitted to operation, and an adrenal aldosterone-producing adenoma was disclosed in every single case. Two patients with primary aldosteronism demonstrated a significant suppression of aldosterone production to 62 and 68 per cent, respectively. Adrenal micronodular hyperplasia was verified in one case and suspected in the other. A significant suppression of aldosterone production was observed in 4 of 5 patients with aldosteronism and normal or high plasma renin levels. The combination of low plasma renin and autonomy of aldosterone production offers a high degree of certainty for the presence of an aldosterone-producing adenoma.

Citations

Jun 1, 1984·Australian and New Zealand Journal of Medicine·G S StokesB A Mennie
Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·M StowasserG J Slater
Sep 1, 1984·Hypertension·O B HollandC E Gomez-Sanchez
Oct 28, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Christina WesterdahlAnders Isaksson
Jan 1, 1980·Scandinavian Journal of Urology and Nephrology·J O LundE Hansner
Jan 1, 1981·Acta Medica Scandinavica·J O LundJ Giese
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Martin C KammerlBernhard K Krämer
Jan 1, 1985·Acta Medica Scandinavica·B HesseM Damkjaer Nielsen
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·J O LundF Rasmussen

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