Fluence rate-dependent photobleaching of intratumorally administered Pc 4 does not predict tumor growth delay.

Photochemistry and Photobiology
Timothy M Baran, Thomas H Foster

Abstract

We examined effects of fluence rate on the photobleaching of the photosensitizer Pc 4 during photodynamic therapy (PDT) and the relationship between photobleaching and tumor response to PDT. BALB/c mice with intradermal EMT6 tumors were given 0.03 mg kg(-1) Pc 4 by intratumor injection and irradiated at 667 nm with an irradiance of 50 or 150 mW cm(-2) to a fluence of 100 J cm(-2). While no cures were attained, significant tumor growth delay was demonstrated at both irradiances compared with drug-only controls. There was no significant difference in tumor responses to these two irradiances (P = 0.857). Fluorescence spectroscopy was used to monitor the bleaching of Pc 4 during irradiation, with more rapid bleaching with respect to fluence shown at the higher irradiance. No significant correlation was found between fluorescence photobleaching and tumor regrowth for the data interpreted as a whole. Within each treatment group, weak associations between photobleaching and outcome were observed. In the 50 mW cm(-2) group, enhanced photobleaching was associated with prolonged growth delay (P = 0.188), while at 150 mW cm(-2) this trend was reversed (P = 0.308). Thus, it appears that Pc 4 photobleaching is not a strong predictor of indi...Continue Reading

References

Aug 1, 1995·Journal of Photochemistry and Photobiology. B, Biology·H HolmesG Weagle
Feb 1, 1993·Photochemistry and Photobiology·N L OleinickM E Kenney
Apr 14, 2006·The Journal of Physical Chemistry. a·H M AnulaMichael A J Rodgers
Jun 20, 2007·Photochemistry and Photobiology·Chao ShengBrian W Pogue
Jul 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William J CottrellAllan R Oseroff

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Citations

Nov 29, 2013·Photodiagnosis and Photodynamic Therapy·Ron R Allison, Keyvan Moghissi
Feb 28, 2013·Photochemistry and Photobiology·Imran RizviTayyaba Hasan
Feb 6, 2017·Scientific Reports·M A SirotkinaN D Gladkova
Apr 14, 2018·ACS Applied Materials & Interfaces·Yuhua JiaPeng Xu

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