Fluid and penicillin G dynamics in polyethylene chambers implanted subcutaneously in rabbits.

Antimicrobial Agents and Chemotherapy
R R TightC A Rotilie

Abstract

Chemical and cellular characteristics of fluid within subcutaneously implanted polyethylene chambers in rabbits were studied over a 3-month period. The fluid attained a relatively stable protein and cellular composition which was consistent with a mononuclear exudate. After a single dose of intramuscular penicillin G, the antibacterial activity of chamber fluid was found to be dynamic and similar to the serum antibacterial activity. This animal model may be useful for in vivo studies of the interaction of microorganisms with antimicrobial agents.

References

Mar 10, 1973·British Medical Journal·G D ChisholmL P Garrod
Aug 1, 1973·Antimicrobial Agents and Chemotherapy·W G GardnerR L Perkins

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Citations

Dec 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·C R Clarke
Dec 1, 1976·Antimicrobial Agents and Chemotherapy·D N GerdingR E Manion
Apr 1, 1977·Antimicrobial Agents and Chemotherapy·C CarbonS Lamotte-Barrillon
Feb 1, 1980·Antimicrobial Agents and Chemotherapy·R R Tight, A C White
Aug 1, 1980·Antimicrobial Agents and Chemotherapy·R R Tight
Jan 1, 1979·Scandinavian Journal of Infectious Diseases·B R Bergman
Jan 1, 1981·Scandinavian Journal of Infectious Diseases. Supplementum·B Hoffstedt
Jun 1, 1976·Infection and Immunity·R R Tight, R L Perkins

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