Fluid and pharmacological agents for adhesion prevention after gynaecological surgery

The Cochrane Database of Systematic Reviews
M MetwallyP Vandekerckhove

Abstract

Pelvic surgery is associated with high rates of both de novo adhesion formation and adhesion reformation. Since subsequent fertility is reduced with increasing severity of periadnexal adhesions, pelvic adhesions will remain a clinical problem in infertility patients. Steroids, antihistamines and heparin were amongst the first substances to be advocated for adhesion prevention. More recently icodextrin 4%, hyaluronic acid agents and SprayGel have been used. This review aims to evaluate the role of fluid and pharmacological agents in the prevention of adhesions in fertility-conserving gynaecological surgery. To investigate fluid and pharmacological agents for adhesion prevention when used as adjuvants during pelvic surgery. This review has drawn on the search strategy developed for the Menstrual Disorders and Subfertility Group. The following databases were searched: the Cochrane Menstrual Disorders and Subfertility Group Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE. Randomised controlled trials investigating the use of fluid and pharmacological agents to prevent adhesion formation after fertility-conserving gynaecological surgery. Data extraction and analysis was performed in...Continue Reading

Citations

Jan 1, 2014·Reproductive Biology and Endocrinology : RB&E·Alessandro ConfortiAdam Magos
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