Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases

Journal of Neurochemistry
Ann BrinkmalmH Zetterberg

Abstract

Neurodegenerative dementias constitute a broad group of diseases in which abnormally folded proteins accumulate in specific brain regions and result in tissue reactions that eventually cause neuronal dysfunction and degeneration. Depending on where in the brain this happens, symptoms appear which may be used to classify the disorders on clinical grounds. However, brain changes in neurodegenerative dementias start to accumulate many years prior to symptom onset and there is a poor correlation between the clinical picture and what pathology that is the most likely to cause it. Thus, novel drug candidates having disease-modifying effects that is targeting the underlying pathology and changes the course of the disease needs to be defined using objective biomarker-based measures since the clinical symptoms are often non-specific and overlap between different disorders. Furthermore, the treatment should ideally be initiated as soon as symptoms are evident or when biomarkers confirm an underlying pathology (pre-clinical phase of the disease) to reduce irreversible damage to, for example, neurons, synapses and axons. Clinical trials in the pre-clinical phase bring a greater importance to biomarkers since by definition the clinical effe...Continue Reading

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Jan 1, 1991·Acta Neuropathologica·G P WangI Grundke-Iqbal
Apr 20, 1991·Lancet·C M van DuijnC Van Broeckhoven
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Jan 1, 1994·International Psychogeriatrics·K BlennowL Svennerholm
Jan 1, 1996·Acta Neurologica Scandinavica. Supplementum·H Braak, E Braak
Feb 1, 1997·Trends in Neurosciences·L I Benowitz, A Routtenberg
May 1, 1997·Journal of the Neurological Sciences·A TamaokaH Mori
May 23, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·E NiederwolfsgruberB Grubeck-Loebenstein
Mar 29, 2001·Physiological Reviews·D J Selkoe
Oct 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·I-Fan WangC-K James Shen
Oct 26, 2002·Science·Dennis J Selkoe
Apr 24, 2003·JAMA : the Journal of the American Medical Association·Trey SunderlandRobert M Cohen
Feb 25, 2005·The Journal of Experimental Medicine·Kazuya TakahashiHarald Neumann
Oct 20, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Laurent RamontFrançois-Xavier Maquart
Dec 31, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Laura ParkkinenIrina Alafuzoff
Mar 2, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Omar M A El-AgnafDavid Allsop
Apr 12, 2006·Archives of Neurology·Daniela GalimbertiElio Scarpini
Aug 1, 2006·Lancet·Kaj BlennowHenrik Zetterberg
Oct 3, 2006·Brain : a Journal of Neurology·Katharina BuergerHarald Hampel
Jan 30, 2007·Experimental Neurology·Qiao-Xin LiMalcolm K Horne
Feb 23, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·D de JongM M Verbeek
Mar 22, 2007·Dementia and Geriatric Cognitive Disorders·Oskar HanssonKaj Blennow
Mar 27, 2007·Journal of the American Society for Mass Spectrometry·Randall J BatemanKevin E Yarasheski
Jun 15, 2007·The Journal of Biological Chemistry·Diane P HangerBrian H Anderton
Jul 3, 2007·Cellular and Molecular Life Sciences : CMLS·F Hernández, J Avila
Jan 10, 2008·Neuro-degenerative Diseases·Robin BarbourTamie J Chilcote

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Citations

Oct 19, 2019·Journal of Neurochemistry·Mark R Cookson
Dec 15, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Sara HallOskar Hansson
Dec 14, 2019·Neurology and Therapy·Nicholas J AshtonKaj Blennow
Oct 9, 2020·Expert Review of Proteomics·Sonia MazzucchiFilippo Baldacci
Nov 3, 2020·Frontiers in Aging Neuroscience·Yang XiangYongjian Yang
Nov 1, 2020·Trends in Pharmacological Sciences·Lorenzo GaetaniLucilla Parnetti
Jun 23, 2020·Journal of Proteomics·Elisabetta Chiaradia, Ingrid Miller

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