Fluid dynamics modeling for synchronizing surface plasmon resonance and quartz crystal microbalance as tools for biomolecular and targeted drug delivery studies

Journal of Colloid and Interface Science
Tapani ViitalaAlex Bunker

Abstract

We have used computational fluid dynamics modeling (CFD) to synchronize the flow conditions in the flow channels of two complementary surface-sensitive characterization techniques: surface plasmon resonance (SPR) and quartz crystal microbalance (QCM). Since the footprint of the flow channels of the two devices is specified by their function, the flow behavior can only be varied either by altering the height of the flow channel, or altering the volumetric rate of flow (flow rate) through the channel. The relevant quantity that must be calibrated is the shear strain on the measurement surface (center and bottom) of the flow channel. Our CFD modeling shows that the flow behavior is in the Stokes flow regime. We were thus able to generate a scaling expression with parameters for flow rate and flow channel height for each of the two devices: f(QCM)=2.64f(SPR)(h(QCM)/h(SPR)(2), where f(QCM) and f(SPR) are the flow rates in the SPR and QCM flow channels, respectively, and h(QCM)/h(SPR) is the ratio of the heights of the two channels. We demonstrate the success of our calibration procedure through the combined use of commercially available SPR and QCM flow channel devices on both a biomolecular interaction system of surface immobilized...Continue Reading

References

Nov 16, 1999·Biochimica Et Biophysica Acta·I VikholmJ Peltonen
Mar 22, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·E ReimhultB Kasemo
Jan 11, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Tapani ViitalaSusanne K Wiedmer
Feb 12, 2009·ACS Nano·Omid C Farokhzad, Robert Langer

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Citations

Aug 29, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Huamin LiangMarjo Yliperttula
Jul 3, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Hirokazu SetoYoshiko Miura
Feb 26, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Niko GranqvistTapani Viitala
Jan 26, 2021·Frontiers in Chemistry·Cecilia Yamil ChainMaría Elena Vela

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