Abstract
Considering steady laminar flow in a two-dimensional symmetric branching channel with local occlusions, a finite element model has been developed to study velocity fields including reverse flow regions, pressure profiles and wall shear stress distributions for different Reynolds numbers, bifurcation angles and lumen reductions. The flow analysis has been extended to include a new submodel for the pseudo-transient formation of plaque at sites and deposition rates defined by the physical characteristics of the flow. Specifically, simulating the onset of atherosclerotic lesions, sinusoidal plaque layers have been placed in areas of critically low wall shear stresses, and simulating the growth of particle depositions, plaque layers have been added in a stepwise fashion in regions of critically high and low shear. Thus two somewhat conflicting hypothetical correlations between critical wall shear stress levels and atheroma have been tested and a solution has been postulated. The validated computer simulation model is a predictive tool for analyzing the effects of local changes in wall curvature due to surgical reconstruction and/or atherosclerotic lesions, and for investigating the design of aortic bifurcations which mitigate plaque...Continue Reading
Citations
Jan 1, 1993·International Journal of Bio-medical Computing·P N TandonV K Katiyar
Nov 1, 1995·Journal of Biomechanics·R S SalzarR T Eppink
Jan 1, 1996·Journal of Biomechanics·D Lee, J J Chiu
May 21, 2005·Medical Engineering & Physics·Siobhan O'CallaghanTimothy McGloughlin
May 1, 1997·Computers in Biology and Medicine·A RedaelliF Inzoli
Dec 1, 1996·Journal of Biomechanics·M LeiJ P Archie
Jun 19, 2001·Medical Engineering & Physics·L BerbichR Benkirane
Aug 1, 1995·Journal of Biomechanical Engineering·M LeiG A Truskey
Dec 18, 2013·Biomedical Engineering Online·Dhanjoo N Ghista, Foad Kabinejadian
Aug 1, 1996·Journal of Biomechanical Engineering·K HayashiT Naiki
Jun 10, 2006·International Journal of Cardiology·Michail I PapafaklisLampros K Michalis
Oct 24, 2002·Neurological Research·Jens Frings-NaberschulteKnut Möller
Apr 1, 1997·Journal of Vascular Surgery·M LeiC Kleinstreuer
Nov 7, 2015·Medical & Biological Engineering & Computing·Akbar ZamanO Anwar Bég
Feb 1, 1997·Journal of Biomechanical Engineering·Y ZhaoB B Lieber
May 30, 2008·Angiology·Christos V BourantasLampros K Michalis