Fluid forces shape the embryonic heart: Insights from zebrafish

Current Topics in Developmental Biology
Pragya Sidhwani, Deborah Yelon

Abstract

Heart formation involves a complex series of tissue rearrangements, during which regions of the developing organ expand, bend, converge, and protrude in order to create the specific shapes of important cardiac components. Much of this morphogenesis takes place while cardiac function is underway, with blood flowing through the rapidly contracting chambers. Fluid forces are therefore likely to influence the regulation of cardiac morphogenesis, but it is not yet clear how these biomechanical cues direct specific cellular behaviors. In recent years, the optical accessibility and genetic amenability of zebrafish embryos have facilitated unique opportunities to integrate the analysis of flow parameters with the molecular and cellular dynamics underlying cardiogenesis. Consequently, we are making progress toward a comprehensive view of the biomechanical regulation of cardiac chamber emergence, atrioventricular canal differentiation, and ventricular trabeculation. In this review, we highlight a series of studies in zebrafish that have provided new insight into how cardiac function can shape cardiac morphology, with a particular focus on how hemodynamics can impact cardiac cell behavior. Over the long-term, this knowledge will undoubted...Continue Reading

Citations

Apr 10, 2020·Circulation Research·Anna O'Donnell, Katherine E Yutzey
Jan 15, 2020·Cold Spring Harbor Perspectives in Biology·Vincent Christoffels, Bjarke Jensen
Oct 23, 2019·Cells·Paola GallardoSilvia Salas-Pino
Feb 13, 2021·Journal of Cardiovascular Development and Disease·Huseyin Enes Salman, Huseyin Cagatay Yalcin
Mar 15, 2021·Current Opinion in Hematology·Claudia Jasmin Rödel, Salim Abdelilah-Seyfried
Mar 29, 2021·Biomechanics and Modeling in Mechanobiology·Sheldon HoChoon Hwai Yap
Jan 15, 2022·PLoS Biology·Renee Wei-Yan ChowJulien Vermot

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