Fluid-induced lung injury-role of TRPV4 channels

Pflügers Archiv : European journal of physiology
Shailesh BihariAndrew D Bersten

Abstract

Administration of bolus intravenous fluid is associated with respiratory dysfunction and increased mortality, findings with no clear mechanistic explanation. The objective of this study was to examine whether bolus intravenous (i.v.) fluid administration results in acute lung injury in a rat model and further, to examine whether this injury is associated with transient receptor potential vallinoid (TRPV)4 channel function and endothelial inflammatory response. Healthy male Sprague-Dawley rats were administered 60 ml/kg 0.9% saline i.v. over 30 min. Manifestation of acute lung injury was assessed by lung physiology, morphology, and markers of inflammation. The role of TRPV4 channels in fluid-induced lung injury was subsequently examined by the administration of ruthenium red (RR) in this established rat model and again in TRPV4 KO mice. In endothelial cell culture, permeability and P-selectin expression were measured following TRPV4 agonist with and without antagonist; 0.9% saline resulted in an increase in lung water, lavage protein and phospholipase A2, and plasma angiopoietin-2, with worsening in arterial blood oxygen (PaO2), lung elastance, surfactant activity, and lung histological injury score. These effects were ameliorat...Continue Reading

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Citations

May 19, 2018·Pharmaceuticals·Benedikt FelsAlbrecht Schwab
Apr 19, 2019·Journal of Applied Physiology·Shailesh BihariAndrew D Bersten
Jun 3, 2020·International Journal of Molecular Sciences·Tamara RosenbaumFrancisco Torres-Quiroz
May 14, 2021·Frontiers in Molecular Biosciences·Liangliang LiuTingting Zhou
Sep 5, 2021·European Journal of Applied Physiology·Hanmo LiShailesh Bihari
May 8, 2021·The Annals of Thoracic Surgery·Nathan HaywoodVictor E Laubach

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Methods Mentioned

BETA
lavage
enzyme-linked immunosorbent assay
bronchoalveolar
Protein Assay
ELISA
electrophoresis
PCR
transgenic

Software Mentioned

C Flow Sampler
xCELLigence
PASW
SPSS

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