Abstract
Objectives: We investigated the association of fluid overload and oxygenation in critically sick children, and their correlation with various outcomes (duration of ventilation, ICU stay, and mortality). We also assessed whether renal angina index (RAI) at admission can predict mortality or acute kidney injury (AKI) on day 3 after admission. Design and setting: Prospective study, pediatric intensive care in a tertiary hospital. Duration: June 2013-June 2014. Patients: Patients were included if they needed invasive mechanical ventilation for >24 h and had an indwelling arterial catheter. Patients with congenital heart disease or those who received renal replacement therapy (RRT) were excluded. Methods: Oxygenation index, fluid overload percent (daily, cumulative), RAI at admission and pediatric logistic organ dysfunction (PELOD) score were obtained in all critically ill children. KDIGO classification was used to define AKI, using both creatinine and urine output criteria. Admission data for determination of RAI included the use of vasopressors, invasive mechanical ventilation, percent fluid overload, and change in kidney function (estimated creatinine clearance). Univariable and multivariable approaches were used to assess the re...Continue Reading
References
May 1, 1992·The American Review of Respiratory Disease·J P MitchellD P Schuster
Oct 1, 1991·Chest·D SchullerD P Schuster
Jul 1, 1988·The American Journal of Emergency Medicine·C E Saunders
Jun 5, 2001·Pediatrics·S L GoldsteinR Sachdeva
Oct 28, 2003·Annals of Surgery·Birgitte BrandstrupUNKNOWN Danish Study Group on Perioperative Fluid Therapy
Nov 2, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Robert S GillespieJordan M Symons
Jan 28, 2005·Kidney International·Stuart L GoldsteinJames D Fortenberry
Sep 30, 2005·Intensive Care Medicine·Anupama UpadyaConstantine A Manthous
May 23, 2006·The New England Journal of Medicine·UNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials NetworkAndrea L Harabin
Jun 6, 2008·Critical Care : the Official Journal of the Critical Care Forum·Didier PayenUNKNOWN Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators
Mar 26, 2009·Chest·Claire V MurphyMarin H Kollef
Mar 28, 2009·Critical Care Medicine·Joe BrierleyAaron Zuckerberg
Mar 31, 2009·Journal of Critical Care·Leslie W HayesAshita J Tolwani
May 14, 2009·Kidney International·Josée BouchardUNKNOWN Program to Improve Care in Acute Renal Disease (PICARD) Study Group
Jan 1, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Scott M SutherlandStuart L Goldstein
Mar 12, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Morgan E GramsUNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network
May 3, 2011·Intensive Care Medicine·David T SelewskiMichael Heung
Jul 16, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ayse A ArikanLaura L Loftis
Aug 23, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael HeungAkinlolu O Ojo
Jul 25, 2012·Critical Care Medicine·Stacey L ValentineUNKNOWN Acute Respiratory Distress Syndrome Clinical Research Network (ARDSNet)
Dec 20, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Matthew A HazleNeal B Blatt
Sep 21, 2013·Kidney International·Rajit K BasuStuart L Goldstein
Mar 29, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Rajit K BasuStuart L Goldstein
Sep 12, 2014·British Journal of Anaesthesia·S GoldsteinUNKNOWN ADQI XII Investigators Group
Apr 18, 2015·BMC Nephrology·Rajit K BasuUNKNOWN Prospective Pediatric AKI Research Group (ppAKI)
Citations
Jan 12, 2020·Indian Journal of Pediatrics·Sidharth Kumar SethiRupesh Raina
Jun 10, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Sainath RamanLuregn J Schlapbach
Nov 15, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jay L KoynerClaudio Ronco
Aug 29, 2020·BMC Nephrology·Linlin HuangXiaozhong Li
May 21, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Pilar Anton-MartinVinai Modem
Feb 7, 2020·The American Journal of Emergency Medicine·Holly R HansonRajit K Basu
Oct 24, 2020·Critical Care : the Official Journal of the Critical Care Forum·Yogen SinghJoris Lemson
Feb 16, 2021·Frontiers in Pediatrics·Xiaomei DaiYanhong Li
Feb 11, 2021·Clinics·Maria Olinda Nogueira ÁvilaEmmanuel A Burdmann
Apr 29, 2021·Seminars in Dialysis·David Askenazi, Rajit K Basu
May 21, 2021·Pediatric Research·Sanjay WazirRupesh Raina
Jun 10, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Francisco Ribeiro-MourãoAugusto Ribeiro
Aug 17, 2021·Frontiers in Pediatrics·Rupesh RainaRonith Chakraborty
Jan 1, 2022·Pediatrics·Julie C FitzgeraldUNKNOWN Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative
Jan 4, 2022·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jitendra MeenaGeorgie Mathew
Jan 13, 2022·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sidharth Kumar SethiSanjay Wazir