PMID: 9177874Mar 1, 1997Paper

Fluid resuscitation following a burn injury: implications of a mathematical model of microvascular exchange

Burns : Journal of the International Society for Burn Injuries
J BertT Lund

Abstract

A validated mathematical model of microvascular exchange in thermally injured humans has been used to predict the consequences of different forms of resuscitation and potential modes of action of pharmaceuticals on the distribution and transport of fluid and macromolecules in the body. Specially, for 10 and/or 50 per cent burn surface area injuries, predictions are presented for no resuscitation, resuscitation with the Parkland formula (a high fluid and low protein formulation) and resuscitation with the Evans formula (a low fluid and high protein formulation). As expected, Parkland formula resuscitation leads to interstitial accumulation of excess fluid, while use of the Evans formula leads to interstitial accumulation of excessive amounts of proteins. The hypothetical effects of pharmaceuticals on the transport barrier properties of the microvascular barrier and on the highly negative tissue pressure generated postburn in the injured tissue were also investigated. Simulations predict a relatively greater amelioration of the acute postburn edema through modulation of the postburn tissue pressure effects.

References

May 1, 1990·The Journal of Burn Care & Rehabilitation·F WienerT Groth
Jun 1, 1995·Computer Methods and Programs in Biomedicine·R T AmpratwumJ L Bert
Sep 1, 1993·Computer Methods and Programs in Biomedicine·C ChappleJ L Bert
Aug 1, 1993·Burns : Journal of the International Society for Burn Injuries·L Roa, T Gómez-Cía
Aug 1, 1993·Burns : Journal of the International Society for Burn Injuries·T Gómez-Cía, L Roa

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Citations

Mar 21, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Gary AnYoram Vodovotz
Mar 29, 2003·American Journal of Respiratory and Critical Care Medicine·Perenlei EnkhbaatarDaniel Traber
Apr 26, 2008·PLoS Computational Biology·Yoram VodovotzGary An
Sep 8, 2016·Critical Care Clinics·Robert Cartotto, David Greenhalgh
Nov 13, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Robert Cartotto, Jeannie Callum
Mar 27, 2001·The Journal of Trauma·B VenkateshJ Fraser

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