Abstract
Several hemoglobin (Hb)-based oxygen carriers are available for use in clinical situations, but their use risks inducing cardiovascular dysfunction as a result of Hb interacting with nitric oxide. Hb vesicles (HbV) are liposome-encapsulated purified human Hb with polyethylene glycol chains at the surface. This study evaluated the effects of HbV on hemodynamics, tissue and systemic oxygenation, and osmotic pressure after fluid resuscitation in an acute hemorrhagic shock model. Hemorrhagic shock was induced in 24 anesthetized mechanically ventilated male rabbits by withdrawing blood to a mean arterial blood pressure (MAP) of 30 to 35 mmHg over 15 min and maintaining this state for 30 min. The animals were resuscitated by replacing the blood with equal volumes of HbV in recombinant human albumin solution (HbV/rHSA), rHSA alone, or Ringer lactated solution (RL), or with three times the withdrawn volume of RL and observed for 2 h. Fluid resuscitation restored MAP, central venous pressure, and cardiac index values, but these fell again within 2 h in rabbits treated with RL. Fluid resuscitation using HbV/rHSA immediately increased MAP and cardiac index but not systemic vascular resistance, maintained a high level of oxygen consumption...Continue Reading
References
Jan 1, 1978·Clinical Pharmacology and Therapeutics·J P SavitskyJ D Arnold
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S J HoffmanG L Stetler
Feb 1, 1995·Free Radical Biology & Medicine·A I Alayash
Jul 14, 1998·Nature Biotechnology·D H DohertyD D Lemon
Aug 15, 1998·Journal of the American College of Surgeons·S A GouldG S Moss
Sep 6, 2000·Vox Sanguinis·R M Winslow
Apr 20, 2001·Nature·J Knight
Apr 20, 2001·Nature·C Lok
Aug 31, 2001·Biophysical Chemistry·M R McCarthyR M Winslow
Mar 28, 2002·Anesthesia and Analgesia·Juraj SprungPatrick J O'Hara
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Hiromi SakaiEishun Tsuchida
Oct 12, 2002·Journal of the American College of Surgeons·Steven A GouldGerald S Moss
Apr 19, 2003·Journal of Internal Medicine·T M S Chang
Mar 30, 2004·Artificial Organs·Thomas Ming Swi Chang
Mar 30, 2004·Biomaterials·Hiromi SakaiEishun Tsuchida
Jun 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Sep 24, 2004·Transfusion·Paul W Buehler, Abdu I Alayash
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Apr 2, 2005·Shock·Michael T HandriganJames L Atkins
Apr 9, 2005·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Y SmaniC Vigneron
Jul 27, 2005·Shock·Françoise ArnaudDaniel Freilich
Sep 2, 2005·Shock·Ernest E MooreAnirban Banerjee
Citations
May 22, 2013·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yuka SaitoYukihiro Kondo
Jun 4, 2008·Shock·Hiromi SakaiKoichi Kobayashi
Dec 17, 2011·Artificial Organs·Hitoshi IkegawaHisashi Sugimoto
Jul 22, 2008·Critical Care : the Official Journal of the Critical Care Forum·Martin K AngeleIrshad H Chaudry
Jan 11, 2007·Biomedical Research·Yoshitugu GotoAtsuhiro Sakamoto
Mar 25, 2011·Drug Metabolism Reviews·Kazuaki TaguchiMasaki Otagiri
Feb 1, 2012·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Manabu YamamotoHiromi Sakai
Apr 17, 2007·Journal of Molecular and Cellular Cardiology·Diana Diesen, Jonathan S Stamler
Aug 2, 2008·Journal of Biomedical Materials Research. Part a·Hiromi SakaiEishun Tsuchida
Nov 29, 2007·Journal of Internal Medicine·H SakaiE Tsuchida
Mar 16, 2017·Journal of Functional Biomaterials·Hiromi Sakai
Apr 18, 2017·Journal of Pharmaceutical Sciences·Kazuaki TaguchiMasaki Otagiri
Jul 25, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yoshitaka YamanashiAtsuhiro Sakamoto
Feb 12, 2009·Bioconjugate Chemistry·Eishun TsuchidaKoichi Kobayashi