Fluid secretion in the duodenum and intestinal handling of water and electrolytes in Zollinger-Ellison syndrome

The American Journal of Digestive Diseases
J C RambaudJ J Bernier


The slow marker perfusion technique was used in five patients with the Zollinger-Ellison syndrome in order to determine the basal and postcibal flow rates of fluids passing the duodenojejunal junction and distal ileum, and the composition of those fluids. Fecal water and electrolyte excretions were also measured. The 24-hr outputs at the ligament of Treitz were markedly increased, while fecal losses were normal or only slightly increased. Thus, the overall intestinal reabsorption of water was 96%. Fasting rates of fluid and electrolyte flow at the ligament of Treitz were also measured during a basal period, followed by a period of continuous gastric aspiration. Removal of gastric secretion had the following effects on the fluid passing through the duodenum: (1) dramatic decrease in flow rate; (2) an increase in osmolality, from hypotonicity to isotonicity; (3) rise of pH, from acid to alkaline values; (4) a decrease of PCO2, from high to normal values. No increase in fasting plasma levels of immunoreactive secretin and motilin was observed in Zollinger-Ellison syndrome, whereas normal subjects respond to acid in the duodenum by a marked rise in the circulating levels of these hormones. These facts suggest that, in Zollinger-Ell...Continue Reading


Dec 1, 1975·The American Journal of Physiology·R G Fiddian-Green, W Silen
Apr 24, 1976·Lancet·P MitzneggL Demling
Dec 1, 1976·Gut·T E AdrianA J Barnes
Jul 1, 1969·The American Journal of Physiology·G F Stening, M I Grossman
Jan 1, 1969·Scandinavian Journal of Gastroenterology·K G Wormsley
Jan 1, 1968·Journal of Applied Physiology·K H SoergelJ A Harris
Mar 1, 1968·The American Journal of Digestive Diseases·H B Cook, A B French
Jun 1, 1968·Archives of Internal Medicine·C M MansbachM P Tyor


Oct 1, 1981·Digestive Diseases and Sciences·R PalmaJ J Bernier
Jan 1, 1985·Seminars in Roentgenology·W J DoddsW D Foley
Aug 28, 1982·Lancet·N W Read
Sep 16, 2004·QJM : Monthly Journal of the Association of Physicians·N ZalunardoM L Halperin
Jan 1, 1991·Journal of Veterinary Internal Medicine·E B BreitschwerdtE V De Buysscher
May 1, 1994·Gut·C Steadman, P Kerlin
Mar 25, 2006·The Journal of Physiology·Misa MizumoriYasutada Akiba
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·G J Krejs

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