Fluid-structure interaction modeling of calcific aortic valve disease using patient-specific three-dimensional calcification scans

Medical & Biological Engineering & Computing
Rotem HaleviRami Haj-Ali

Abstract

Calcific aortic valve disease (CAVD) is characterized by calcification accumulation and thickening of the aortic valve cusps, leading to stenosis. The importance of fluid flow shear stress in the initiation and regulation of CAVD progression is well known and has been studied recently using fluid-structure interaction (FSI) models. While cusp calcifications are three-dimensional (3D) masses, previously published FSI models have represented them as either stiffened or thickened two-dimensional (2D) cusps. This study investigates the hemodynamic effect of these calcifications employing FSI models using 3D patient-specific calcification masses. A new reverse calcification technique (RCT) is used for modeling different stages of calcification growth based on the spatial distribution of calcification density. The RCT is applied to generate the 3D calcification deposits reconstructed from a patient-specific CT scans. Our results showed that consideration of 3D calcification deposits led to both higher fluid shear stresses and unique fluid shear stress distribution on the aortic side of the cusps that may have an impact on the calcification growth rate. However, the flow did not seem to affect the geometry of the calcification during ...Continue Reading

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Citations

Nov 4, 2017·Journal of Biomechanical Engineering·Karin LavonRami Haj-Ali
Nov 11, 2019·Medical & Biological Engineering & Computing·Bin GaoYu Chang
Jun 11, 2020·Cardiovascular Engineering and Technology·Diana M C de OliveiraDaniel M Espino
Jul 22, 2018·Journal of Biomechanical Engineering·Rotem HaleviRami Haj-Ali
Aug 23, 2018·Cardiovascular Engineering and Technology·Giulia LuraghiJosè Fèlix Rodriguez Matas
Jul 27, 2017·Medical & Biological Engineering & Computing·Mohamad Shukri ZakariaKamarul Arifin Ahmad
Mar 5, 2021·Perfusion·Mohammad Javad Ghasemi PourShahram Etemadi Haghighi

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