Fluid-Structure Interactions Analysis of Shear-Induced Modulation of a Mesenchymal Stem Cell: An Image-Based Study

Artificial Organs
Roza Vaez GhaemiZakieh Alihemmati

Abstract

Although effects of biochemical modulation of stem cells have been widely investigated, only recent advances have been made in the identification of mechanical conditioning on cell signaling pathways. Experimental investigations quantifying the micromechanical environment of mesenchymal stem cells (MSCs) are challenging while computational approaches can predict their behavior due to in vitro stimulations. This study introduces a 3D cell-specific finite element model simulating large deformations of MSCs. Here emphasizing cell mechanical modulation which represents the most challenging multiphysics phenomena in sub-cellular level, we focused on an approach attempting to elicit unique responses of a cell under fluid flow. Fluorescent staining of MSCs was performed in order to visualize the MSC morphology and develop a geometrically accurate model of it based on a confocal 3D image. We developed a 3D model of a cell fixed in a microchannel under fluid flow and then solved the numerical model by fluid-structure interactions method. By imposing flow characteristics representative of vigorous in vitro conditions, the model predicts that the employed external flow induces significant localized effective stress in the nucleo-cytoplasm...Continue Reading

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Citations

Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Zakieh AlihemmatiMohammad Salehi
Dec 18, 2018·Journal of Tissue Engineering and Regenerative Medicine·Esmaeel RahimpourZahra Mollahoseini
Mar 11, 2017·Artificial Organs·Angela T Hadsell, Paul S Malchesky
Jul 9, 2021·Journal of Materials Science. Materials in Medicine·Mehdi MoradkhaniBahram Ahmadian

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