PMID: 11902176Oct 1, 1979Paper

Fluid volumes changes induced by spaceflight

Acta Astronautica
P C Johnson

Abstract

The blood volume (BV), plasma volume (PV), and extracellular fluid volume changes produced in crewmembers during spaceflights of 11-84 days were compared to changes after 14 or 28 days of bedrest. Spaceflight and bedrest produce approximately equal BV changes but the recorded PV change after spaceflight was less. However, the diurnal change in PV may explain the smaller decreases recorded after spaceflight. The cardiovascular deconditioning caused by spaceflight and bedrest was compared using the mean heart rate response to lower body negative pressure (LBNP) testing at -50 mmHg pressure. These tests show approximately equal LBNP produced heart rate changes after bedrest and spaceflight. A countermeasure which includes 4 hr of LBNP treatment at -30 mmHg and the ingestion of one l. of saline was studied and found capable of returning the heart rate response and the PV of bedrested subjects to control (prebedrest) levels suggesting that it would be useful to the crewmembers after a spaceflight.

References

Jun 1, 1975·Comparative Biochemistry and Physiology. A, Comparative Physiology·J H Lewis

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Citations

Oct 1, 1991·Journal of Clinical Pharmacology·M A FreyM W Bungo
Oct 1, 1991·Journal of Clinical Pharmacology·J B Charles, C M Lathers
Sep 1, 1981·Acta Astronautica·A Cogoli
Jan 1, 1988·Acta Astronautica·C S LeachN M Cintrón
Sep 1, 1990·Acta Astronautica·C S LeachA E Nicogossian
Jan 1, 1991·Experimental Gerontology·J B Charles, M W Bungo
Jul 1, 2006·Computers in Biology and Medicine·Richard L SummersThomas G Coleman
Jan 1, 1983·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·D R CramerH P Klein
Aug 3, 2004·Journal of Clinical Pharmacology·Annemarie GraebeHartmut Derendorf
Jun 29, 2018·The Journal of Experimental Biology·Alexander A Andreev-AndrievskiyOlga L Vinogradova
Jul 1, 1994·The Journal of Experimental Zoology·S J SimskeM W Luttges
Oct 1, 1996·Medicine and Science in Sports and Exercise·J B CharlesC F Sawin

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