Fluindione-induced acute generalised exanthematous pustulosis confirmed by patch testing

Annales de dermatologie et de vénéréologie
M ChtiouiE Mahé

Abstract

Fluindione is an oral anticoagulant belonging to the vitamin K antagonist class. Although fluindione is very widely prescribed in France, few cases of cutaneous drug reactions have been reported. Below we describe a case of acute generalised exanthematous pustulosis due to fluindione as confirmed by patch-testing. A 70-year-old woman was hospitalised for diffuse erythematous and pustular rash 48hours after initiation of fluindione treatment for cardiac arrhythmia. A diagnosis of fluindione-induced acute generalised exanthematous pustulosis was made. After withdrawal of fluindione, the eruption cleared up within eight days. Warfarin was then used without skin reaction. Subsequent patch-tests were positive for fluindione. These signs were consistent with fluindione-induced acute generalised exanthematous pustulosis. A causative role of fluindione is very likely in view of the rapid onset after initiation, improvement after withdrawal and positive patch tests. Skin patch-testing, which is easily performed, can be extremely helpful in determining a causal relationship with medication.

References

Feb 16, 2002·Contact Dermatitis·A BarbaudUNKNOWN European Society of Contact Dermatitis
Apr 12, 2003·Pharmacotherapy·Alex C SpyropoulosPatricia Jenkins
Mar 4, 2005·The Journal of Pharmacology and Experimental Therapeutics·Dean J NaisbittB Kevin Park
Mar 16, 2005·Toxicology·Annick Barbaud
Dec 21, 2006·Clinical Nephrology·S BelmouazG Touchard

❮ Previous
Next ❯

Citations

Jun 23, 2015·La Revue de médecine interne·S NgoH Lévesque
May 22, 2009·Current Opinion in Allergy and Clinical Immunology·Sima Halevy
Jul 2, 2009·Current Opinion in Allergy and Clinical Immunology
Aug 20, 2009·Current Opinion in Allergy and Clinical Immunology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Annales de dermatologie et de vénéréologie
E FrouinJ-C Guillaume
Annales de dermatologie et de vénéréologie
C ThurotJ-C Beani
Cutaneous and Ocular Toxicology
Gunseli OzturkGulsen Kandiloglu
Annales de dermatologie et de vénéréologie
C Merklen-DjafriM-L Batard
© 2022 Meta ULC. All rights reserved