PMID: 3766098Jul 1, 1986Paper

Flunitrazepam-fentanyl-induced sedation and analgesia for bone marrow aspiration and needle biopsy in children

Acta Anaesthesiologica Scandinavica
E L MaunukselaM A Siimes

Abstract

We describe the use of flunitrazepam and fentanyl to produce sedation and analgesia, as an alternative to general anesthesia, for 96 children with malignancies or hematologic diseases, undergoing 122 bone marrow examinations (BME). In 82 cases there was no reaction to the puncture. Most children had complete amnesia and only two remembered some pain. In 10% the sedation and analgesia was considered inadequate and barbiturate was given; seven out of these 12 children were under the age of 3 years. During 117 procedures the children maintained adequate spontaneous ventilation; in five cases the ventilation was assisted. In 13 cases there were minor side-effects including drowsiness and nausea. One child had a short apnea after the procedure.

References

Aug 1, 1979·British Journal of Anaesthesia·H StoeckelJ Schüttler
Apr 1, 1977·Anaesthesia·L StamenkovićJ Spierdijk
Dec 1, 1980·British Journal of Anaesthesia·A C McKay, J W Dundee
Oct 1, 1984·Pediatric Clinics of North America·N L Schechter
Dec 1, 1980·British Journal of Anaesthesia·F PuppoJ Zattoni

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Citations

Mar 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P J McGrath, G G Johnson
Jul 13, 2002·Clinical Psychology Review·Wendy G Kuppenheimer, Ronald T Brown
Sep 12, 2003·Journal of Pain and Symptom Management·Philine VanhelleputteSteven Vanderschueren
Feb 16, 2013·Journal of Pediatric Hematology/oncology·Icten E InceDuyguhan Isguven
Jun 1, 1991·Psychological Reports·S B KvistM A Siimes
Aug 1, 1990·Current Problems in Pediatrics·L K ZeltzerN L Schechter
Sep 1, 1990·Annals of Emergency Medicine·S M GreenN E Johnson
Jan 1, 1993·Cardiovascular and Interventional Radiology·L H MonseinN J Olson
Apr 18, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H M KerstensA G Hanselaar

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