PMID: 44632Dec 1, 1979

Flunitrazepam versus placebo premedication for minor surgery

Acta Anaesthesiologica Scandinavica
J KantoM Mansikka

Abstract

The clinical effects of oral flunitrazepam (2 mg on the night before operation followed by 2 mg on the morning of operation) and placebo as premedicants were tested in a double-blind study in 81 gynaecological patients. The separate or total concentrations of flunitrazepam and its demethylated metabolite in plasma (measured by gas chromatography) were correlated with the clinical effects of flunitrapam premedication, assessed both sugjectively and objectively. In most parameters tested (sleep on the night before operation, sedation, apprehension, headache, pulse rate), there was a positive, significant difference between the flunitrazepam group (n = 44) and the placebo group (n = 37). No significant difference was found between the two groups in emetic effect, excitement, systolic blood pressure increase, and vene-puncture, but the patients receiving flunitrazepam felt significantly more dizziness. The temperature of the left forefinger before, during and after the anaesthesia did not vary significantly between the two groups. There was no correlation between the plasma concentration of flunitrazepam and its demethylated metabolite (separate or total concentrations) and any of the parameters tested before induction of anaesthes...Continue Reading

References

Apr 4, 1998·Journal of Clinical Anesthesia·M I WittenbergK K Tremper
Dec 1, 1983·Anaesthesia·S SjovallO Viinamäki
Apr 1, 1983·Acta Anaesthesiologica Scandinavica·A Risbo, J F Schmidt
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·J Kanto
Feb 1, 1985·Acta Anaesthesiologica Scandinavica·M S Hüttel, U Bang
Apr 1, 1987·British Journal of Clinical Pharmacology·J KantoY Pitkänen

Citations

Jan 1, 1976·Acta Anaesthesiologica Scandinavica·K Korttila, M Linnoila
Oct 1, 1977·British Journal of Anaesthesia·M A MattilaK Säilä
Mar 1, 1978·British Journal of Anaesthesia·K KorttilaM Hytönen
Sep 1, 1977·Anesthesiology·W H ForrestB W Brown
Nov 1, 1977·British Journal of Anaesthesia·L KangasM Mansikka
Mar 1, 1970·British Journal of Anaesthesia·J W DUNDEE, W H Haslett
Apr 1, 1971·British Journal of Anaesthesia·M Johnstone
Jul 1, 1962·British Journal of Anaesthesia·J W DUNDEER M NICHOLL

Related Concepts

Dilatation and Curettage
Anti-Anxiety Effect
Premedication
Clinical Trials
Surgical Procedures, Minor
Placebos
Double-Blind Method

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