PMID: 44632Dec 1, 1979

Flunitrazepam versus placebo premedication for minor surgery

Acta Anaesthesiologica Scandinavica
J KantoM Mansikka


The clinical effects of oral flunitrazepam (2 mg on the night before operation followed by 2 mg on the morning of operation) and placebo as premedicants were tested in a double-blind study in 81 gynaecological patients. The separate or total concentrations of flunitrazepam and its demethylated metabolite in plasma (measured by gas chromatography) were correlated with the clinical effects of flunitrapam premedication, assessed both sugjectively and objectively. In most parameters tested (sleep on the night before operation, sedation, apprehension, headache, pulse rate), there was a positive, significant difference between the flunitrazepam group (n = 44) and the placebo group (n = 37). No significant difference was found between the two groups in emetic effect, excitement, systolic blood pressure increase, and vene-puncture, but the patients receiving flunitrazepam felt significantly more dizziness. The temperature of the left forefinger before, during and after the anaesthesia did not vary significantly between the two groups. There was no correlation between the plasma concentration of flunitrazepam and its demethylated metabolite (separate or total concentrations) and any of the parameters tested before induction of anaesthes...Continue Reading


Apr 4, 1998·Journal of Clinical Anesthesia·M I WittenbergK K Tremper
Dec 1, 1983·Anaesthesia·S SjovallO Viinamäki
Apr 1, 1983·Acta Anaesthesiologica Scandinavica·A Risbo, J F Schmidt
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·J Kanto
Feb 1, 1985·Acta Anaesthesiologica Scandinavica·M S Hüttel, U Bang
Apr 1, 1987·British Journal of Clinical Pharmacology·J KantoY Pitkänen


Jan 1, 1976·Acta Anaesthesiologica Scandinavica·K Korttila, M Linnoila
Oct 1, 1977·British Journal of Anaesthesia·M A MattilaK Säilä
Mar 1, 1978·British Journal of Anaesthesia·K KorttilaM Hytönen
Sep 1, 1977·Anesthesiology·W H ForrestB W Brown
Nov 1, 1977·British Journal of Anaesthesia·L KangasM Mansikka
Mar 1, 1970·British Journal of Anaesthesia·J W DUNDEE, W H Haslett
Apr 1, 1971·British Journal of Anaesthesia·M Johnstone
Jul 1, 1962·British Journal of Anaesthesia·J W DUNDEER M NICHOLL

Related Concepts

Dilatation and Curettage
Anti-Anxiety Effect
Clinical Trials
Surgical Procedures, Minor
Double-Blind Method

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.