Fluorenyl-Loaded Quatsome Nanostructured Fluorescent Probes

ACS Omega
Xinglei LiuKevin D Belfield

Abstract

Delivery of hydrophobic materials in biological systems, for example, contrast agents or drugs, is an obdurate challenge, severely restricting the use of materials with otherwise advantageous properties. The synthesis and characterization of a highly stable and water-soluble nanovesicle, referred to as a quatsome (QS, vesicle prepared from cholesterol and amphiphilic quaternary amines), that allowed the nanostructuration of a nonwater soluble fluorene-based probe are reported. Photophysical properties of fluorenyl-quatsome nanovesicles were investigated via ultraviolet-visible absorption and fluorescence spectroscopy in various solvents. Colloidal stability and morphology of the nanostructured fluorescent probes were studied via cryogenic transmission electronic microscopy, revealing a "patchy" quatsome vascular morphology. As an example of the utility of these fluorescent nanoprobes, examination of cellular distribution was evaluated in HCT 116 (an epithelial colorectal carcinoma cell line) and COS-7 (an African green monkey kidney cell line) cell lines, demonstrating the selective localization of C-QS and M-QS vesicles in lysosomes with high Pearson's colocalization coefficient, where C-QS and M-QS refer to quatsomes prepared...Continue Reading

References

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Citations

Jun 6, 2018·Chemistry : a European Journal·Antonio ArdizzoneJaume Veciana
Dec 18, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Guillem Vargas-NadalNora Ventosa
Aug 23, 2019·Bioconjugate Chemistry·Tinghan ZhaoKevin D Belfield
Nov 29, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Dorothy A SilbaughBrian A Korgel
Apr 10, 2020·ACS Applied Materials & Interfaces·Judit Morla-FolchNora Ventosa

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Methods Mentioned

BETA
dynamic light scattering
Fluorescence
fluorescence imaging
column chromatography
light scattering

Software Mentioned

Fiji
SUSP
DELOS

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