Fluorescein angiography of the bladder: technique and relevance to bladder cancer and interstitial cystitis patients

The Journal of Urology
P E ZimmernG E Leach

Abstract

Fluorescein angiography has been used in the study of bleeding vessels, neovascularity, tumors and ischemic tissues in a variety of disorders. This pilot study was designed to evaluate the feasibility, safety and relevance of this interesting technology for the evaluation of bladder wall vessels in patients with interstitial cystitis and bladder cancer. Five patients with National Institutes of Health defined interstitial cystitis symptoms and 10 with bladder cancer were studied during cytoscopy while they were under general anesthesia. A yellow-green barrier filter (520 nm.) was placed over the cystoscope eyepiece and a blue exciter filter (465 nm.) was attached to the light source. Patients received a 5 ml. bolus of 10% fluorescein intravenously. After hydrodistension, glomerulations in interstitial cystitis patients were more prominent with fluorescein angiography and occurred in the venule phase. Areas of papillary transitional cell tumor and carcinoma in situ developed a brilliant yellow-green fluorescence. Adjacent normal urothelium was nonfluorescent and provided a contrasting dark background facilitating the detection of all lesions. No allergic reaction or other adverse effect related to the fluorescein injection was o...Continue Reading

References

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Citations

Nov 14, 2002·European Urology·Marie-Ange D'HallewinFrançois Guillemin
Oct 23, 1997·The Journal of Urology·S C Campbell
Feb 8, 2002·The Journal of Urology·Frank ReiherSteven C Campbell
Jul 9, 2005·BJU International·Dirk ZaakChristian Stief

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