Abstract
Although the use of video-assisted thoracoscopy has improved the diagnostic accuracy in patients presenting with pleural diseases, not all biopsies performed are conclusive and staging of the disease is not always optimal. Fluorescence diagnosis (FD) with 5-aminolaevulinic acid (5-ALA) has been used in the diagnostic workup for various malignancies. The impact of 5-ALA-mediated FD on diagnosis and staging during video-assisted thoracoscopy was examined. Prospective, single-center study. National cancer center. Twenty-six patients with nonconclusive pleural effusions who were scheduled for video-assisted thoracoscopy. Eligible patients were administered 1,500 to 2,500 mg po of 5-ALA before video-assisted thoracoscopy. After conventional inspection with white light, fluorescence inspection of the pleural cavity was performed (D-LIGHT Auto Fluorescent System; Karl Storz; Tuttlingen, Germany). Biopsy specimens of both normal and abnormal sites, as determined from white light and FD inspection, were obtained for histologic examination. One patient was ineligible, and two patients were not evaluable because of equipment failure. One postoperative death occurred due to preexisting myocardial disease. In another patient, an empyema dev...Continue Reading
References
Feb 1, 1990·Chest·S LamA E Profio
Jul 17, 1993·Lancet·W E GrantS G Bown
May 20, 1999·Photochemistry and Photobiology·M ZellwegerG Wagnières
Jan 26, 2000·Journal of Endourology·C R RiedlH Pflüger
Jan 26, 2000·The Laryngoscope·A LeunigR Baumgartner
Apr 3, 2001·International Journal of Cancer. Journal International Du Cancer·J MoanV Iani
Oct 26, 2001·Gastrointestinal Endoscopy·B MayingerE G Hahn
Jan 25, 2002·Annals of Surgery·Johannes GahlenChristian Herfarth
Nov 28, 2002·Thorax·R L ProsstJ Gahlen
Dec 7, 2002·Gynecologic Oncology·John K ChanYona Tadir
Jan 31, 2004·Surgical Endoscopy·C J KeltyM W R Reed
Apr 10, 2004·Cancer·Martin LöningGereon Hüttmann
Feb 11, 2005·The Journal of the American Association of Gynecologic Laparoscopists·Olaf BuchweitzLudwig Kiesel
Citations
Nov 30, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Lorena RodriguezAdriana Casas
Feb 22, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Oleg PikinAli Amiraliev
Jan 16, 2008·Current Opinion in Critical Care·Patricia R M Rocco, Paolo Pelosi
Jan 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·John E Heffner
Aug 28, 2009·Journal of Occupational Medicine and Toxicology·Nicolas SchönfeldSebastian Ott
Jul 1, 2007·Annals of Thoracic Medicine·Ayman BishayMichael Baumann
Nov 15, 2011·Acta neurochirurgica·Marcel A KampMichael Sabel
May 27, 2014·Expert Review of Respiratory Medicine·Julius Janssen
Apr 5, 2013·Expert Opinion on Medical Diagnostics·Francisco Rodriguez-Panadero, Beatriz Romero-Romero
Jan 28, 2016·Neurosurgical Review·Nicholas FerraroRicardo J Komotar
Nov 21, 2014·Chest·Feng WangYanbing Wu
Feb 16, 2013·Clinics in Chest Medicine·Pyng Lee, Henri G Colt
Apr 21, 2009·The Journal of Surgical Research·M Raschid Hoda, Gralf Popken
Feb 5, 2008·Mayo Clinic Proceedings·John E Heffner, Jeffrey S Klein
Aug 19, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jitsuo UsudaHarubumi Kato
Jun 9, 2016·Translational Oncology·Haruaki HinoJun Nakajima
Mar 19, 2016·Current Opinion in Pulmonary Medicine·Pyng Lee, Praveen N Mathur
Jun 24, 2011·Therapeutic Advances in Respiratory Disease·Kay Choong See, Pyng Lee
Sep 27, 2019·Frontiers in Surgery·Joseph F GeorgesSteven Yocom
Aug 27, 2016·Oncotarget·Marcel A KampMichael Sabel
Jun 27, 2020·Expert Review of Respiratory Medicine·Faisal ShaikhFabien Maldonado
Nov 24, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·David Fielding
Nov 7, 2019·Brain Tumor Research and Treatment·So Young JiChul Kee Park
Apr 16, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ilias PorfyridisAndreas Georgiou