Fluorescence excitation photography of epidermal cellular proliferation

The British Journal of Dermatology
E Gutierrez-HerreraW Franco

Abstract

Fluorescence excitation provides the ability to interrogate innate molecules whose radiation emission correlates with specific functional states of tissue. The present study demonstrates the effectiveness of a novel ultraviolet (UV) fluorescence excitation photography system in its ability to image rapidly proliferating epidermal skin lesions by capturing endogenous fluorescence emissions attributed to tryptophan. A clinical prototype UV fluorescence excitation photography system was used to acquire images of endogenous fluorescence ascribed to tryptophan. Twelve human subjects and 11 ex vivo samples with various skin lesions consistently exhibited increased endogenous fluorescence at 340-nm wavelength upon excitation at 295 nm in rapid epidermal proliferations, including psoriasis, actinic keratoses and basal cell carcinoma, compared with surrounding normal skin. In contrast, nonproliferating lesions showed decreased fluorescence. This simple but robust point-and-shoot imaging system may offer a clinically useful, noncontact, noninvasive device for the diagnosis and detection of skin disease. As opposed to structural imaging modalities, fluorescence excitation imaging at 295/340-nm wavelengths offers high-sensitivity, wide-fie...Continue Reading

References

Jun 1, 1992·Metabolism: Clinical and Experimental·P R OdettiR Rolandi
Jan 1, 1997·Lasers in Surgery and Medicine·J C ZhangS P Schantz
Jan 7, 1998·Journal of the American Academy of Dermatology·J WelzelR Engelhardt
Nov 6, 1998·The Journal of Investigative Dermatology·N KolliasR R Anderson
Sep 21, 2000·The Journal of Investigative Dermatology·R GilliesN Kollias
Mar 29, 2001·Photochemistry and Photobiology·L BrancaleonN Kollias
Apr 5, 2001·The Journal of Investigative Dermatology·R NaH C Wulf
Jul 20, 2001·Photochemistry and Photobiology·A G DoukasN Kollias
Jul 26, 2003·The Journal of Investigative Dermatology·Anna N YaroslavskyR Rox Anderson
Jan 29, 2005·The Journal of Investigative Dermatology·Susanne AstnerSalvador González
Feb 21, 2006·Journal of the American Academy of Dermatology·Susanne AstnerErnesto Gonzalez
Oct 7, 2008·The British Journal of Dermatology·R M R HearnR S Dawe
Aug 23, 2011·Clinics in Dermatology·Dawn Hirokawa, Jason B Lee
Nov 29, 2012·The Journal of Investigative Dermatology·Adaobi NwaneshiuduRoger C Young
Oct 17, 2015·The British Journal of Dermatology·W FrancoA Doukas

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Citations

May 22, 2016·The British Journal of Dermatology·S W Youn
Mar 8, 2017·Experimental Dermatology·Paulo R BargoGeorgios N Stamatas
Sep 22, 2017·Journal of Biomedical Optics·Antonio Ortega-MartinezWalfre Franco
Jun 17, 2020·Lasers in Surgery and Medicine·Vinzent Kevin OrtnerPeter Alshede Philipsen
Mar 22, 2020·Photodiagnosis and Photodynamic Therapy·Jacob A MojeskiGyorgy Paragh

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