Fluorescence-Guided Visualization of Soft-Tissue Sarcomas by Targeting Vascular Endothelial Growth Factor A: A Phase 1 Single-Center Clinical Trial.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Pieter J SteinkampGooitzen M van Dam

Abstract

Resection of soft-tissue sarcoma (STS) is accompanied by a high rate of tumor-positive surgical margins (14%-34%), which potentially lead to decreased disease-free survival. Vascular endothelial growth factor A is overexpressed in malignant tumors, including STS, and can be targeted with bevacizumab-800CW during fluorescence-guided surgery for real-time tumor detection. In this phase 1 clinical trial, we determined the feasibility, safety, and optimal dose of bevacizumab-800CW for fluorescence-guided surgery in STS for in vivo and ex vivo tumor detection. Methods: Patients with a histopathologic diagnosis of STS were included. In the dose-escalation phase, patients received bevacizumab-800CW intravenously 3 d before surgery (10, 25, and 50 mg; n = 8). In the subsequent dose-expansion phase, 7 additional patients received bevacizumab-800CW at the optimal dose. Fluorescence images were obtained in vivo and ex vivo during all stages of standard care. The optimal dose was determined by calculating in vivo and ex vivo tumor-to-background ratios (TBR) and correlating these results with histopathology. Results: Fifteen patients with STS completed this study. All tumors could be visualized during in vivo and ex vivo imaging. The optima...Continue Reading

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Citations

May 6, 2021·International Journal of Molecular Sciences·Vincent Q SierLukas J A C Hawinkels
Jul 29, 2021·Journal of Surgical Oncology·Sophie J M ReijersWinan J Van Houdt
Oct 12, 2021·European Journal of Nuclear Medicine and Molecular Imaging·H M SchouwS Kruijff
Nov 6, 2021·European Journal of Nuclear Medicine and Molecular Imaging·J VonkMjh Witjes
Nov 16, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Vytautas KučikasMarc A M J van Zandvoort

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