[Fluorescence histochemical and microfluorometrical investigations of pigmentary tumors of the skin (author's transl)].

Archives of Dermatological Research
E PaulL Illig

Abstract

Junction nevus, dermal nevus, melanosis circumscripta praecancerosa Dubreuilh, superficial spreading melanoma, and nodular melanoma were investigated and characterized by use of the formalin induced fluorescence method (FIF). In the vicinity of junctional nevus cell clusters and near tumor cells of the superficial spreading melanoma increased numbers of melanocytes are found. These show different types of dendritic branching. Spherical nevus cells however are completely devoid of dendritic processes. On the other hand, the atypical pigment cells in melanosis circumscripta praecancerosa Dubreuilh exhibit a shape similar to that of melanocytes, whereas the globular cells of superficial spreading melanoma have the appearance of nevus cells. The arrangement of nodular melanoma cells resembles that observed in dermal nevus. However the characteristic decrease in fluorescence intensity from epidermal junction to deeper dermis as observed in the dermal nevus was missed in nodular melanomas. Dendritic pigment cells displaying formalin induced fluorescence (FIF) could be demonstrated in all types of malignant melanomas investigated in the present study. The fluorophores of the pigment lesions are characterized microspectrofluorimetrical...Continue Reading

References

Mar 21, 1974·Zeitschrift für Zellforschung und mikroskopische Anatomie·A CalasJ P Collin
Jan 1, 1974·Virchows Archiv. A, Pathological Anatomy and Histology·W Tilgen, U W Schnyder
Jan 1, 1969·Virchows Archiv. A: Pathology. Pathologische Anatomie·F W Rost, J M Polak
Jul 1, 1971·The Journal of Investigative Dermatology·A J Cochran
Apr 1, 1967·American Journal of Surgery·J DavisG K Higgins
Mar 1, 1954·The Journal of Investigative Dermatology·S W BECKER
May 1, 1965·Archives of Dermatology·Y MISHIMA
Mar 1, 1960·Postgraduate Medicine·G T PACK, J DAVIS
Jan 1, 1951·Cancer·P MASSON
Jul 1, 1947·Physiological Zoology·M E RAWLES

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Citations

Apr 1, 1983·The Journal of Dermatology·F H Rampen
Dec 15, 1976·Archives of Dermatological Research·E Paul, L Illig

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