Fluorescence imaging and whole-body biodistribution of near-infrared-emitting quantum dots after subcutaneous injection for regional lymph node mapping in mice.

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Emilie PicFrédéric Marchal

Abstract

This study compares fluorescence imaging to mass spectroscopy (inductively coupled plasma-mass spectroscopy, ICP-MS) for detection of quantum dots (QDs) in sentinel lymph node (LN) mapping of breast cancer. We study the accumulation of near-infrared-emitting QDs into regional LNs and their whole-body biodistribution in mice after subcutaneous injection, using in vivo fluorescence imaging and ex vivo elemental analysis by ICP-MS. We show that the QD accumulation in regional LNs is detectable by fluorescence imaging as early as 5 min post-delivery. Their concentration reaches a maximum at 4 h then decreases over a 10-day observation period. These data are confirmed by ICP-MS. The QD uptake in other organs, assessed by ICP-MS, increases steadily over time; however, its overall level remains rather low. Fluorescence imaging can be used as a non-invasive alternative to ICP-MS to follow the QD accumulation kinetics into regional LNs.

References

Sep 25, 1998·Science·M BruchezA P Alivisatos
Mar 14, 2001·Journal of the American College of Surgeons·P J TanisB B Kroon
Feb 20, 2002·The British Journal of Surgery·M Noguchi
Jul 30, 2002·Anesthesia and Analgesia·Leslie L MontgomeryPatrick I Borgen
Dec 3, 2002·Science·Benoit DubertretAlbert Libchaber
Dec 9, 2003·Nature Biotechnology·Sungjee KimJohn V Frangioni
Dec 29, 2004·The Annals of Thoracic Surgery·Edward G SolteszTomislav Mihaljevic
Mar 15, 2005·Nature Biotechnology·Vasilis NtziachristosRalph Weissleder
Mar 15, 2005·Seminars in Nuclear Medicine·Ronald N KaleyaJonathan S Zager
Apr 12, 2005·The Journal of Thoracic and Cardiovascular Surgery·Cherie P ParungoJohn V Frangioni
May 13, 2005·Chest·Cherie P ParungoJohn V Frangioni
Feb 18, 2006·Annals of Surgical Oncology·Edward G SolteszJohn V Frangioni
Apr 7, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kathrin SchererAndreas J Bircher
Aug 15, 2006·Biochemical and Biophysical Research Communications·William W YuVicki L Colvin
Oct 31, 2006·Expert Review of Anticancer Therapy·Alberta FerrariRenzo Dionigi
Dec 29, 2006·Small·Binil Itty IpeChristof M Niemeyer
Feb 1, 2007·Bioconjugate Chemistry·Byron BallouMarcel P Bruchez
Mar 10, 2007·Annals of the Royal College of Surgeons of England·Dennis W ChickenMohammed R S Keshtgar
Mar 28, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Bilal MujtabaDiwakar Jain
Apr 4, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Neera V GopeePaul C Howard
May 25, 2007·The Journal of Investigative Dermatology·Yukihiro HamaHisataka Kobayashi
May 29, 2007·Nano Letters·Hisataka KobayashiPeter L Choyke
Aug 21, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Meike L SchipperSanjiv S Gambhir
Sep 20, 2007·Journal of Surgical Oncology·K SatoD N Krag
Sep 25, 2007·Nature Biotechnology·Hak Soo ChoiJohn V Frangioni
Nov 8, 2007·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Kazuhiko Sato
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Parmeswaran DiagaradjaneSunil Krishnan
May 23, 2008·Toxicology and Applied Pharmacology·Zhen ChenXiaohong Fang
Jul 18, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephan T SternScott E McNeil
Sep 5, 2008·Environmental Science & Technology·Pinpin LinRaymond S H Yang
Oct 25, 2008·Journal of Nanobiotechnology·Lin WangRebecca L Carrier
Dec 17, 2008·Environmental Health Perspectives·Jorina GeysPeter H M Hoet
Jan 10, 2009·International Journal of Surgery·Francesca RoveraRenzo Dionigi
Jan 14, 2009·Particle and Fibre Toxicology·Nicklas Raun JacobsenHåkan Wallin
Mar 12, 2009·Anti-cancer Agents in Medicinal Chemistry·Emilie PicFrédéric Marchal

❮ Previous
Next ❯

Citations

Sep 18, 2012·Advanced Drug Delivery Reviews·Elsa CassetteThomas Pons
Dec 4, 2012·Sensors·Marketa RyvolovaRene Kizek
Aug 3, 2012·Immunotherapy·Arpit BhargavaPradyumna Kumar Mishra
Jun 25, 2014·Biomaterials·Tingting DaiGuangdong Zhou
Mar 22, 2014·International Journal of Nanomedicine·Sarwat B RizviAlexander M Seifalian
Oct 5, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Jae Jun ParkGi Jeong Cheon
Aug 1, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ligeng Xu, Chunying Chen
Mar 26, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Dina RadenkovicAlexander M Seifalian
Mar 18, 2015·Chemical Society Reviews·K David Wegner, Niko Hildebrandt
Oct 2, 2012·Biomedical Optics Express·Franklin TellierPatrick Poulet
Oct 26, 2012·Current Opinion in Allergy and Clinical Immunology·Emanuela Fabiola Craparo, Maria Luisa Bondì
Mar 30, 2012·Nanomaterials·Chai-Hoon Quek, Kam W Leong
Sep 1, 2018·Journal of Nanobiotechnology·Travis J AntesEduardo Marbán
May 10, 2019·Science and Technology of Advanced Materials·Shanmugavel Chinnathambi, Naoto Shirahata

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.