PMID: 7522537Aug 1, 1994Paper

Fluorescence in situ hybridisation studies to characterise complete and partial monosomy 7 in myeloid disorders

Genes, Chromosomes & Cancer
B GibbonsL Kearney

Abstract

Eight patients with myeloid disorders characterised by a karyotype including apparent monosomy or partial monosomy 7, in the presence of a ring or marker chromosome, were investigated by fluorescence in situ hybridisation (FISH) with a chromosome 7 centromere-specific probe and an Alu-PCR derived chromosome 7 paint. In 4 of 5 cases a ring chromosome was shown to be of chromosome 7 origin; in one of these the apparent ring was shown to consist solely of chromosome 7 centromeric material, and in the fifth case the ring was derived from chromosome 18. In three cases monosomy 7 had arisen during the course of karyotype evolution and was clearly not the primary cytogenetic abnormality. One further case demonstrated fragmentation and cryptic translocation of chromosome 7 material. In the last case a chromosome described as der(l)t(1;7)(p11;p11) was redefined as dic(1;7)(p11;q11). The application of FISH has enabled a more accurate characterisation of chromosome abnormalities, and extended studies of this type may eventually lead to more precise prognostic groups defined by karyotype.

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Citations

Mar 1, 1997·Blood Reviews·E Johnson, F E Cotter
Jul 24, 2010·Journal of Hematology & Oncology·Shanthi SivendranVesna Najfeld
Jul 17, 2010·Cancer Genetics and Cytogenetics·Libuse LizcovaKyra Michalova
Jan 22, 2008·Cancer Genetics and Cytogenetics·Adriana Zámecníkova
Mar 30, 2007·European Journal of Haematology·Angèle HerryMarc De Braekeleer
Jan 20, 2000·Baillière's Clinical Haematology·F E Cotter
Jan 1, 1998·Hematology·D J Culligan
Jan 1, 1997·Hematology·F E Cotter, E Johnson

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