Fluorescence in situ hybridization reveals trisomy 2q by insertion into 9p in hepatoblastoma

Cancer Genetics and Cytogenetics
E BaloghE Oláh

Abstract

Cytogenetics and fluorescence in situ hybridization (FISH) of a hepatoblastoma are presented. The results of standard chromosome analysis were as follows: 47,XY,+2,add(4)(q35),-9,+20[10]. FISH with the use of whole-chromosome paints revealed partial trisomy of the long arm of chromosome 2 by insertion into chromosome 9. Comparison of the G-banded metaphases with metaphase FISH led to a reinterpretation of the karyotype as: 47,XY,add(4)(q35),der(9)ins(9;2)(p22;q?21q?25),+20. This case supports previous observations that the critical region of trisomy 2 lies between 2q21 and 2qter and shows how partial trisomy 2q may evade detection in G-banded metaphases.

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Citations

Jul 30, 2003·Cancer Genetics and Cytogenetics·B CzepulkowskiS Sadullah
May 17, 2000·Cancer Genetics and Cytogenetics·S K MaL C Chan
Aug 1, 2006·Journal of Biomedicine & Biotechnology·Evan A Farkash, Eline T Luning Prak
Sep 29, 2009·Cancer Genetics and Cytogenetics·Eva StejskalováMarie Jarosová
Dec 20, 2014·Future Oncology·Tatiane Cristina RodriguesCarla Rosenberg
Aug 10, 1999·Luminescence : the Journal of Biological and Chemical Luminescence·P E Stanley, L J Kricka
Sep 14, 2002·Medical and Pediatric Oncology·Marie Annick Buendia

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